Dan Mucida boosted

'The presence of arsenic is not uncommon in antique artifacts. The element is prevalently found in green pigments that were once used to dye clothing, book covers and even artificial flowers, according to Ms. Ritchie. (In the Victorian era, she said, people even ate small amounts of the toxin, hoping to make their skin appear pale.)'
HT @mucida

nytimes.com/2023/09/23/science

Dan Mucida boosted

"We find that purchases dominate laboratory emissions, accounting for more than 50% of emissions, with a median of 2.7 t CO2e/pers, which is 3 to 4-fold the separate contribution from travel, commutes and heating"

cc @mucida

biorxiv.org/content/10.1101/20

Dan Mucida boosted

"The effects of climate change driven by human activity are now part of the daily news cycle, and time is running out for decisive action."

Lab & academia's responsibilities in the climate emergency. A privilege to collaborate with @mucida & Rachel on this Nature Immunology commentary.

nature.com/articles/s41590-023

Dan Mucida boosted

A reference framework to normalize human lymphocyte numbers in ageing.

'In this study, we analyze cross-sectional numbers of mainly T lymphocytes (CD3+, CD3+CD4+, and CD3+CD8+) and their subpopulations (naive and memory) from 673 healthy Dutch individuals ranging from infancy to adulthood (0鈥62 y). We fitted the data by a delayed exponential function and estimated parameters for each lymphocyte subset.'

journals.aai.org/jimmunol/arti

Dan Mucida boosted

It was a pleasure to reconnect with Jos茅 Roberto de Toledo of Brazil's Piau铆 magazine a couple years after participating in his Portuguese language Pandemic Podcast, "Luz no fim da Quarentena" (ht @mucida).
On UOL's An谩lise de Not铆cia we talked about the new and .
馃憞 Starts around min 27 (in Portuguese)

youtube.com/watch?v=N68508vkQ-

10/ Thanks to everyone involved in this 25 year-old project, particularly Ainsley Lockhart, Aubrey Reed, Tiago Castro, Calvin Herman, Ci莽a Canesso and all Mucida lab members, particularly Roham Parsa, who developed the fate-mapping model used in collaboration with the Nussenzweig lab.

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9/ These findings provide important insights into the mechanisms underlying the ability of the intestinal immune system to tolerate food antigens, and could have implications for the development of new therapies for food allergies.

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8/ The study also identified both steady-state epithelium-adapted CD4+ T cells and tolerance-induced Tregs that recognize dietary antigens, suggesting that both cell types may be critical for preventing inappropriate immune responses to food.

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7/ Such steady-state CD4+ T cell response to food was disrupted by an inflammatory challenge, and protection against food allergy via previous ingestion of the protein (oral tolerance) was associated with Treg clonal expansion and decreased pro-inflammatory gene expression.

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6/ This tissue specialized transcriptional program includes cytotoxic genes on both conventional and regulatory CD4+ T cells (Tregs), also previously addressed by the lab (science.org/doi/10.1126/scienc, or nature.com/articles/s41590-021)

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5/ These observations inform about the antigen sources of CD4 T cell adaptation to the gut epithelium, topic covered by the lab for over a decade (see nature.com/articles/ni.2518)

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4/ Our study found that dietary proteins contribute to the accumulation and clonal selection of antigen-experienced CD4+ T cells in the intestinal epithelium, imprinting a tissue-specific transcriptional program on both conventional and regulatory CD4+ T cells.

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3) Our new study used antigenically defined diets and gnotobiotic models to find individual contributions from food versus microbiota on the profile and T cell receptor repertoire of intestinal CD4+ T cells.

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2/ Ainsley Lockhart, who recently brilliantly defended her thesis, took on this question and answered more comprehensively that I could ever dream when I started working on this question exactly 25 years ago.

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(Thread)

1/ What is the physiological impact of dietary proteins on steady-state T cells? Nelson Vaz and Ana Faria, my undergrad mentors, wondered about this question for decades.

biorxiv.org/content/10.1101/20

Dan Mucida boosted

A new preprint from Ainsley Lockhart & @mucida has, as the cool kids say, just dropped:

"Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells"

biorxiv.org/content/10.1101/20

Dan Mucida boosted

Some of my favorite cover illustrations by Madalena were not selected by editors - like this one for Ilana Gabanyi & @mucida's 2016 paper "Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages"

cell.com/cell/fulltext/S0092-8

madalenaparreira.com

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