10/ Thanks to everyone involved in this 25 year-old project, particularly Ainsley Lockhart, Aubrey Reed, Tiago Castro, Calvin Herman, Ciça Canesso and all Mucida lab members, particularly Roham Parsa, who developed the fate-mapping model used in collaboration with the Nussenzweig lab.
7/ Such steady-state CD4+ T cell response to food was disrupted by an inflammatory challenge, and protection against food allergy via previous ingestion of the protein (oral tolerance) was associated with Treg clonal expansion and decreased pro-inflammatory gene expression.
4/ Our study found that dietary proteins contribute to the accumulation and clonal selection of antigen-experienced CD4+ T cells in the intestinal epithelium, imprinting a tissue-specific transcriptional program on both conventional and regulatory CD4+ T cells.
3) Our new study used antigenically defined diets and gnotobiotic models to find individual contributions from food versus microbiota on the profile and T cell receptor repertoire of intestinal CD4+ T cells.
2/ Ainsley Lockhart, who recently brilliantly defended her thesis, took on this question and answered more comprehensively that I could ever dream when I started working on this question exactly 25 years ago.
Total disaster and we know the ones responsible
---
RT @ScienceMagazine
The Amazon rainforest is one of the most vital major ecosystems on Earth—but it is under threat.
In this issue of Science, researchers underscore the rapid and profound changes occurring in the Amazon resulting from ever-increasing human activity. https://scim.ag/1iX
https://twitter.com/ScienceMagazine/status/1618686477612769280
RT @n8_upham
Lunar New Year visitors to the AZ desert -- morning hike to welcome in the #YearOfTheRabbit 🐇🐰🌵🏜️
@danmucida @carolilucas @florsheim_eb
The King 👑
---
RT @TheKingCenter
‘Letter from Birmingham Jail’: https://www.africa.upenn.edu/Articles_Gen/Letter_Birmingham.html
A masterpiece.
“You deplore the demonstrations taking place in Birmingham. But your statement, I am sorry to say, fails to express a similar concern for the conditions that brought about the demonstrations.”
#MLK #MLKDay
https://twitter.com/TheKingCenter/status/1614994607212822528
❤️
---
RT @LulaOficial
Hoje agradeci os trabalhadores que limparam e reergueram o Palácio do Planalto em pouquíssimos dias, depois do estrago feito por vândalos. Esse é um patrimônio do povo brasileiro, de todos nós. Muito obrigado.
📸: @ricardostuckert
https://twitter.com/LulaOficial/status/1613998712669278219
Rest in Power, REI
---
RT @TheKingCenter
Rest in Peace, #Pele. Thank you for all the joy you brought to the world.
https://twitter.com/TheKingCenter/status/1608558891188494336
Immunologist, professor @RockefellerUniv,
@HHMINews, 🏄🏽♂️@Indonesia 🧗🏻@Cipó anti-racist&anti-fascist @everywhere 🇧🇷 🇺🇸