10/ Thanks to everyone involved in this 25 year-old project, particularly Ainsley Lockhart, Aubrey Reed, Tiago Castro, Calvin Herman, Ciça Canesso and all Mucida lab members, particularly Roham Parsa, who developed the fate-mapping model used in collaboration with the Nussenzweig lab.

Show thread

7/ Such steady-state CD4+ T cell response to food was disrupted by an inflammatory challenge, and protection against food allergy via previous ingestion of the protein (oral tolerance) was associated with Treg clonal expansion and decreased pro-inflammatory gene expression.

Show thread

4/ Our study found that dietary proteins contribute to the accumulation and clonal selection of antigen-experienced CD4+ T cells in the intestinal epithelium, imprinting a tissue-specific transcriptional program on both conventional and regulatory CD4+ T cells.

Show thread

3) Our new study used antigenically defined diets and gnotobiotic models to find individual contributions from food versus microbiota on the profile and T cell receptor repertoire of intestinal CD4+ T cells.

Show thread

2/ Ainsley Lockhart, who recently brilliantly defended her thesis, took on this question and answered more comprehensively that I could ever dream when I started working on this question exactly 25 years ago.

Show thread

Total disaster and we know the ones responsible
---
RT @ScienceMagazine
The Amazon rainforest is one of the most vital major ecosystems on Earth—but it is under threat.

In this issue of Science, researchers underscore the rapid and profound changes occurring in the Amazon resulting from ever-increasing human activity. scim.ag/1iX
twitter.com/ScienceMagazine/st

RT @OnlinePalEng
BREAKING: 8 Palestinians, including an elderly woman, were shot and murdered by Israeli occupation forces during the ongoing military raid into the Jenin camp.

RT @RepRashida
Palestinians may be banned from flying their flag under an apartheid government, but we can still proudly do it at my office. I’m proud to be a Palestinian American and I want the Palestinian people to know that not all Americans support apartheid. No one can erase our existence.

RT @MiltonBituca
"Aí a dor vai nos unir, o fim da dor começa, é assim..."

Yanomami e Nós - Pacto da Vida

(Milton Nascimento e Fernando Brant)

RT @n8_upham
Lunar New Year visitors to the AZ desert -- morning hike to welcome in the 🐇🐰🌵🏜️
@danmucida @carolilucas @florsheim_eb

The King 👑
---
RT @TheKingCenter
‘Letter from Birmingham Jail’: africa.upenn.edu/Articles_Gen/

A masterpiece.

“You deplore the demonstrations taking place in Birmingham. But your statement, I am sorry to say, fails to express a similar concern for the conditions that brought about the demonstrations.”

 
twitter.com/TheKingCenter/stat

❤️
---
RT @LulaOficial
Hoje agradeci os trabalhadores que limparam e reergueram o Palácio do Planalto em pouquíssimos dias, depois do estrago feito por vândalos. Esse é um patrimônio do povo brasileiro, de todos nós. Muito obrigado.

📸: @ricardostuckert
twitter.com/LulaOficial/status

RT @RockefellerUniv
It is with heavy hearts that we announce the passing of our beloved colleague and friend, C. David Allis. Aside from his groundbreaking contributions to biomedical science, David will be remembered for his warmth, humility, and relentless optimism.

RT @randolfeap
O nosso Presidente do Brasil 👍🏼

RT @DiarioOle
⚽️ La pelota JAMÁS los olvidará... 😢

Rest in Power, REI
---
RT @TheKingCenter
Rest in Peace, . Thank you for all the joy you brought to the world.
twitter.com/TheKingCenter/stat

RT @MarraffiniLab
one more about the Argentina world cup win...

Show older
Qoto Mastodon

QOTO: Question Others to Teach Ourselves
An inclusive, Academic Freedom, instance
All cultures welcome.
Hate speech and harassment strictly forbidden.