Let's think of some potential "factors" from a more progressive angle.
"tough on crime" policies which separate parents from their children. That is bad for the mental well-being of their children.
By criminalizing cannabis, there is a higher chance of it containing something extra which might be lethal. Once again, that is surely bad for the mental well-being of their children.
We could go on. These points are politically unpalatable though, particularly the first one.
Even with alcohol, might this not be a coping mechanism? I'm not hearing chatter about mental health services here. Maybe, that is also unpalatable but it is curious how that is uniquely off the table.
The insistent conflation between practices someone might think unwise and abuse also obscures the possibility for sex education, perhaps also for adult populations (i.e. BDSM and other such things). Also, if someone frames any messaging as "anti abuse" or "consent", then someone might well tune that out, as opposed to practicing things safely or something.