A little while ago I asked DALL:E to come up with images of protein designers. This is one result. But Generative AIs are dreaming up novel proteins. So I wrote about what's actually happening: https://cen.acs.org/physical-chemistry/protein-folding/Generative-AI-dreaming-new-proteins/101/i12?utm_source=Staff&utm_medium=Social&utm_campaign=CEN
#ai #proteindesign #chemistry @chemistry
@L_howes @chemistry
That's my favorite way to design proteins, just get around the table with a bunch of friends and build up the lego!
Since you talk about biological validation, I was recently in a lecture held by a Swiss guy (I don't have my notes with me right now).
His group was designing new proteins with genetic algorithms, but the cool part was that the genetic algorithm was a physical and biological one.
They would place a gene encoding a protein inside bacteria, induce random mutations and through microfluidics separate the cells which contained a good protein (they were evaluating the catalytic effects on some reaction). Then they would sequence all the good ones. And reintroduce them in the cycle.
This is quite cool, works and its rapid as well as I think they were processing some thousands proteins per second if I'm not mistaken.
@rastinza @chemistry there is so much interesting work going on in protein design and engineering. It's fascinating to watch!