Rob Beagrie @rbeagrie@qoto.org

#GeneChat need grant writing literature search help. Anyone got a lead on good papers that talk about developing a genetic counseling strategy/outline for polygenic risk scores.... so far found a handful of good papers talking about principles such as below... looking for more!

https://www.ukhillwalking.com/articles/features/my_move_to_the_mountains_life_in_wester_ross-14966

Some objects you have to share immediately after seeing it: a Roman flask in the shape of a fish.
We don't know what flaks in the shape fishes were used for, maybe the shape relates to the content (garum/fish sauce), maybe it was used to hold oil.

On display at Pierides Museum, Larnaka, Cyprus.

Photo: Jeff Amadon via Flickr

#RomanArchaeology

Another #job post: want to do a #postdoc on #epigenetics of #cancer in Oxford? Experience with #bioinformatics? Then apply now! https://dub.sh/licrpd4

#hiring #jobs

Elijah McCoy was born in 1844 in Ontario to formerly-enslaved parents from Kentucky. They saved enough to send him to Scotland to study mechanical #engineering. When he returned and couldn't get work in his field, he took a job as a train oilman and invented a method of automatic lubrication that eliminated the frequent stops trains had to make to oil up axles & bearings. Railroad companies asking for his product rather than copycat devices spawned the phrase "the real McCoy." #BlackHistoryMonth

Abstract submissions are now open for ISMB/ECCB in Lyon, France! Submit your latest work on annotation, prediction, design, and evolution of protein function. Join us this summer!

https://www.iscb.org/ismbeccb2023-submissions/abstracts

Exciting postdoc opportunity with @twoyke here at the Joint Genome Institute @jgi in Berkeley. Great science, great views.

Project involves:
- genome sequencing of single microbial cells
- phylogenetic and functional diversity analysis
- secondary metabolite analysis

For recent work from Tanja's group, see https://www.nytimes.com/2022/06/23/science/giant-bacterium.html

Apply here: https://lbl.referrals.selectminds.com/jobs/microbial-genomics-postdoctoral-fellow-5106

Please boost.

@LBNLBioSci @berkeleylab #NationalLab #Postdoc #Genomics #SingleCell #Berkeley

Happy to announce my new preprint!! done by a talented colleague in which I am the second author. She aimed to find #DNAmethylation marks associated with #BMI in #pregnancy. She managed to replicate many CpG sites!! . Furthermore it was a multi-ancestry study, including both European and South Asian women. Therefore this increases the generalisability of the results.

#epigenetics #epigenomics #EWAS #science #ScienceMastodon

https://www.researchsquare.com/article/rs-2517570/v1

Gos: a declarative library for interactive #genomics visualization in #Python | #Bioinformatics

https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btad050/6998203

On #scienceTwitter, my favourite thing were reading and, on rare occasions, writing "paper/preprint threads". From the researchers I followed and through the #Twitter algorithm, this became my most important source for new #research.

While people start to do the same on #Mastodon, I have the feeling that I miss important work bc no algorithm "saves" it for me if I don't watch my timeline constantly.

Two simple solutions would be: a commonly accepted hashtag that everybody uses when writing "paper threads" or a [...] @ a.gup.pe group with a similar adaptation rate.

#Question 1: is there already a mechanism for this that I missed?
#Question 2: What hashtag or group name?
I saw #TootPrint before. Maybe #PaperInAToot? #PaperInAPost? #PaperInAThread? #PaperPost? #MastoPrint?

Suggestions and boosts, please, we need reach for this! 🤓​

#TwitterMigration #Science #Scientist @phdstudents @academicchatter @neuroscience @cognition

“In conclusion, our first-pass functional genomics null hypothesis showed that we expect a lot of gene regulatory activity by chance... and maybe, just maybe, not everything that the genome does is functional. “. Another piece of evidence that e-qtls are mostly non functional and more often than not happening by chance, just like the fact that you and I look different, genes can be transcriptonally different without consequence.
https://www.biorxiv.org/content/10.1101/2022.12.16.520785v1

An irregular reminder that calling this place "Mastodon" has a bit similar energy as saying "I just sent you a GMail."

"Fediverse" (or "fedi") is a better term.

Mastodon is just one of many software projects that talk to each other to create this multi-instance social network:
https://axbom.com/fediverse/

(kudos to @axbom for this fantastic infographic!)

There are blogs, Reddit-like communities, video instances and many more, all part of fedi.

#TwitterMigration #NewHere

So I understand that the bird site has started blocking links to common/known Mastodon instances, and that doesn't seem like free speech to me. So... I did a thing.

If you go to https://spacekaren.sucks it is now a URL shortener that blocks the twitter user agent. That means you can share that link that will redirect to your Mastodon account without the pouty baby stopping you. If you find this helpful can you boost so others can find it? #TwitterMigration #Mastodon #Musk #introduction

I'm excited about this new #genomics #scRNA #rnaseq preprint from @ariel_hippen! It's a molecular biology deep dive into what happens when you dissociate and single-cell sequence a tissue with the goal of performing deconvolution of bulk tissue.

Some key bits: there are dissociation effects, RNA capture/depletion effects, and potentially some microfluidics effects with the #10X platform. Also, deconvolution algorithms are variably robust to these things.

See more:
https://www.biorxiv.org/content/10.1101/2022.12.04.519045v1

Development's Pathway to Independence programme https://thenode.biologists.com/developments-pathway-to-independence-programme/news/ via @the_Node@twitter.com