(1/3) Neuronal reactivation and replay in the #hippocampus is important for #learning and #memory. So does reactivation induce or modulate synaptic plasticity? We think it does! This is a video abstract made with #blender of our recent paper in #elife.
For higher quality video watch https://www.youtube.com/watch?v=v93Ci-koiNY
@tanjafuchsberger
Beautiful video! In N accumbens, DA is permissive and a signal from amygdala drives reward firing (cf Ambroggi et al Neuron 2008). Is there an amygdala signal driving a coincident signal here, or do you think the DA pulse downstream of that circuit (via amyg->VTA) carries info that the reward was found?
@brendonowicz Thanks! Excellent question.. If that input from the amygdala (via direct or indirect connections) triggers an action potential burst, and DA is present then this could trigger this type of plasticity. We have shown it only for the hippocampus, but it may well also work like that in other brain areas..
