@pixelpaperyarn I've broken up mine in multiple vaults since I use each vault for very different purposes and don't want the gajillion tags and aliases cluttering up each other. I also intend to use different plugins (besides the must-haves that I'll use in every vault) depending on the needs of those vaults.
I've also prepared the shortcuts to those vaults (Obsigames, Obsifood, Obsiwork etc) so I can easily just start up whichever vault I need at the moment.
Everything in one vault just became too unwieldy in long term.