@acjay You're best off blocking the whole instances yourself of certain instances as the instance admins couldn't care less over there.
Qoto has a very open stance here. Whenever possible, we won't suspend (block) servers. We leave that power in the hands of the users, because the users have all the tools available to them.
When an instance actually repeatedly harrass and go out of their way to do so, we might reconsider.
That said, I've blocked a fair amount of instances myself. It takes a bit of time to get to the sweet spot but after that it's a smooth ride.
We prefer this over the walled gardens that some other instances are, who then block more than necessary and make the federated space smaller for themselves.