Philipp Schlegel @uni_matrix@qoto.org

Cabel Sasser is my new hero. His talk at XOXO Conference is absolutely EPIC and a must see that you should watch till the very end. I cried my eyes out (and I have 20 minutes to recover my composure before a conference call): https://www.youtube.com/watch?v=Df_K7pIsfvg

Follow Cabel here: @cabel

My little one is only 3 years old but I will make sure to save this video and show it to her when she's a bit older.

For now, I'll encourage her to follow Cabel's advice: appreciate everything, endlessly ✨

very happy and proud to finally share our work on the evolution of feeding preference in flies! @TomAuer @dahaniel @RibeiroCarlitos and support from many beautiful people (@Benton lab, @Arguello lab, @Simon_Sprecher lab)...hope you like it!
https://www.biorxiv.org/content/10.1101/2024.10.11.617601v1.article-metrics

my god

Whole adult fly brain connectome for FAFB (female adult fly brain) – last year in preprint form, today as an immersive feature in Nature.

140,000 neurons, over 50 million synapses – organised into over 8,000 cell types. (VNC not included.)

https://www.nature.com/immersive/d42859-024-00053-4/index.html

The whole connectome: Dorkenwald et al. 2024 (Seung, Murthy) https://www.nature.com/articles/s41586-024-07558-y

Cell types: Schlegel et al. 2024 (Jefferis) https://www.nature.com/articles/s41586-024-07686-5 by @uni_matrix

Network statistics: Lin et al. 2024 (Murthy) https://www.nature.com/articles/s41586-024-07968-y

Visual system: Garner et al. 2024 (Wernet, Kim) https://www.nature.com/articles/s41586-024-07967-z and Matsliah et al. (Murthy, Seung) https://www.nature.com/articles/s41586-024-07981-1

Seung also put out a solo paper on predicting visual function from the connectome: https://www.nature.com/articles/s41586-024-07953-5

Control of halting in walking: Sapkal et al. 2024 (Bidaye) https://www.nature.com/articles/s41586-024-07854-7

FAFB imaged by @davi 's group back in 2018: https://www.cell.com/cell/fulltext/S0092-8674(18)30787-6

#neuroscience #Drosophila #connectomics #FAFB

We are looking for exceptional #AIScientist|s to join our AI@HHMI initiative at @hhmijanelia. We want to uncover fundamental principles underlying complex biological systems that are inaccessible without new innovations that combine #AI with experimental design. We are strongly committed to #OpenScience and interdisciplinary collaboration.

https://hhmi.wd1.myworkdayjobs.com/en-US/External/job/Janelia-Research-Campus/AI-Scientist_R-3065

If you are interested in how #AI methods can be applied to #model biological systems, this should be interesting for you: https://alleninstitute.org/events/data-driven-discovery-ai-and-modeling-in-biology/
. Presentations and discussions will be live-streamed.

For #SciArtSeptember: 50 EPG neurons from the #Drosophila, segmented from electron microscopy images, rendered in #Blender3d driven by neuVid. This ring of neurons forms part of the fly’s internal compass. As the fly changes its heading, neuronal activity moves around the ring, as shown by the false color gradient. Imaging and reconstruction by #HHMIJanelia and Google Research (www.janelia.org/project-team/flyem/hemibrain); function described by Hulse et al (doi.org/10.7554/eLife.66039).

Can we observe how the injured leg of an animal is regenerated?

We have figured out how to do this in the crustacean Parhyale. Over the course of a week, we can record the entire process of leg regeneration at cell-by-cell resolution.

Our latest preprint describes how we do this and what we see:
https://www.biorxiv.org/content/10.1101/2024.09.11.612529v1

More info/links on https://bsky.app/profile/michalis-averof.bsky.social/post/3l3xonnzt6u2n

Enjoying the fruits of my labor now that I finished my 12-legged 'Carpentopod' table project. See
https://decarpentier.nl/carpentopod for project info. (Or come see it live at Maker Days Eindhoven this 13 & 14 Sept.)

Discovery of spiking network model parameters constrained by neural recordings, using simulation-based inference https://www.biorxiv.org/content/10.1101/2024.08.21.608969v2 #neuroscience

The #CampbellSiegert approximation is a method used in #ComputationalNeuroscience to estimate the #firingrate of a #neuron given a certain input. This approximation is particularly useful for analyzing the firing behavior of neurons that follow a leaky #IntegrateAndFire (#LIF) model or similar models under the influence of stochastic input currents. Here is a short #tutorial that introduces the concept in more detail:

🌍 https://www.fabriziomusacchio.com/blog/2024-09-04-campbell_siegert_approximation/

#CompNeuro #neuroscience #PythonTutorial

Our team is looking for an associate news editor with a background or strong interest in neuroscience, cognition and behavior, to write and edit news articles that educate, challenge and inspire our audience of neuroscientists. To apply, please visit: https://simonsfoundation.wd1.myworkdayjobs.com/en-US/simonsfoundationcareers/job/Associate-News-Editor_R0001667

🐣 New feature 🐣

The quick-select tool now works in 3D! Set the prediction depth and segment cells as before, now across multiple sections automatically.

Plus, you can now quick-select with just a click—no more drawing rectangles 🚀 Try it out now !

A great initiative to boost #OpenAccess academic journals. Basically, you pledge not to serve as peer reviewers for venues that do not make publicly available the research that we review. #NoFreeViewNoReview
Join us! Boosts are appreciated.
#academicchatter #academia
https://nofreeviewnoreview.org/

Modern science relies on (open source) software and hardware, but there is currently no incentive for researchers to provide feedback and improvement suggestions for tools that are use in the scientific community despite how valuable these contributions are to the scientific community as a whole. One possible way forward would be to treat "issue creation" and other Git-based activity as an acceptable form of peer review.

This is an issue and idea I’ve been thinking about for a while.I’d love to flesh it out into an actual set of actionable proposals/suggestions, as well as figuring out which (technological) hurdles would need to be overcome, in a opinion-styled paper - could anyone be interested in working on this together with me?

"Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation" Elizabeth Marin et al. 2024
https://elifesciences.org/reviewed-preprints/97766

"This fundamental study provides a near-comprehensive anatomical description and annotation of neurons in a male Drosophila ventral nerve cord, based on large-scale circuit reconstruction from electron microscopy. This connectome resource will be of substantial interest to neuroscientists interested in sensorimotor control, neural development, and analysis of brain connectivity. However, although the evidence is extensive and compelling, the presentation of results in this very large manuscript lacks clarity and concision."

#Drosophila #neuroscience #connectomics #eLifeAssessment

Are you looking to become an assistant professor in Switzerland? This year you have two chances:
1- We've been re-admitted to the @ERC_Research starting grant program, deadline 15 Oct 2024 https://www.admin.ch/gov/en/start/documentation/media-releases.msg-id-101763.html
2- We still have @snsf_ch starting grants, deadline 15 Jan 2025
In both cases, consider @dee_unil as a host institution, we have excellent conditions and a beautiful campus! 😃
#ERC #StartingGrants