#foxp3
These are public posts tagged with #foxp3. You can interact with them if you have an account anywhere in the fediverse.
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A new study was recently published in Science Translational Medicine investigating antigen specificity in Treg-mediated suppression of effector T cells in a celiac model. 
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What is the TCR specificity of Foxp3+ Tregs? They're as diverse as conventional T cells, but very few antigen-specific Tregs have been described. This lack of specificity leads to many unfounded statements. Let's dive in.
1/ Let's do a deep dive into the best research article on Foxp3+ Tregs this month (January 2025) and highlight its strengths and weaknesses.
'We found that up-regulation of a primate-specific short isoform of PRDM1-S induces expression of SGK1 independent from the evolutionarily conserved long PRDM1, which led to destabilization of #FOXP3 & #Treg dysfunction. This aberrant PRDM1-S/SGK1 axis is shared among other autoimmune diseases.'
#Immunology
https://www.science.org/doi/10.1126/scitranslmed.adp1720
"Here, by comprehensively mapping 3D #chromatin organization during #Treg cell differentiation, we show that Treg-specific chromatin structures were progressively established during its lineage specification, and highly associated with Treg signature gene expression. Additionally, the binding sites of #Foxp3, a Treg lineage specifying #transcription factor, were highly enriched at Treg-specific chromatin loop anchors."
"Notably, TCR-M cells that were predifferentiated toward a regulatory phenotype in vitro maintained stable in vivo #FOXP3 (Forkhead box P3) expression and anti-inflammatory activity whereas #th17
partially converted toward a regulatory phenotype in the injured myocardium."
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.322183
#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473
