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#ft3

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Johannes W. Dietrich @drjwdietrich@qoto.org

Systems biology of #thyroid_homeostasis: Relational stability of two intertwined feedback loops protects #FT3 concentration despite variations in #thyroid's secretory capacity. https://doi.org/10.1177/20420188231158163

The hypothalamic–pituitary–thyroid (HPT) axis.

The HPT axis consists of a network of feedback and feedforward loops that control the thyroid hormones FT4 and FT3.1 The upstream organs provide hierarchical settings and feedforward, namely, the hypothalamus to the pituitary via TRH and the pituitary to the thyroid gland via TSH. The thyroid feeds back to the pituitary and hypothalamus. FT4 is converted to the biologically more active FT3 through a multi-enzyme process, which is partly TSH-dependent. Both FT4 and FT3 provide feedback on TSH and TRH.
Sensitivities of FT3, FT4 and TSH to changes in the FT4 production rate. The fraction of the production rate of FT4 is denoted by v0. (a) If v0 decreases from 1 to 0, FT4 falls, while TSH rises simultaneously (due to reduced feedback by FT4 on TSH). FT3 does not decrease proportionally to FT4 (due to increased feedforward by TSH on FT3). (b) Conversely, if v0 increases from 1 to 15, FT4 increases, TSH decreases. Again, FT3 increases to a relatively lesser extent than FT4. (c) As v0 decreases (a), TSH increases from the normal to the hypothyroid range, but FT3 stays nearly unchanged despite a substantial change in its precursor FT4. (d) With increasing v0, TSH decreases, approaching its lower reference limit and FT4 levels rise substantially more, compared with FT3 levels.
Comparison of model predictions with clinical results. (a) In untreated patients (n = 357) with autoimmune thyroiditis (AIT) and subclinical hypothyroidism FT3 homeostasis was preserved, as the FT4–TSH ratio varied widely. In contrast, FT3 escaped from homeostasis in athyreotic patients (n = 77) with thyroid carcinoma on levothyroxine (LT4) replacement (Ca). The slopes in the two groups were statistically significantly different (non-linear general additive model, p = 0.02), as predicted by modelling. (b) The transition from thyroid health to severe hypothyroidism is modelled in a hypothetical case and clinically observed in individual patients. As the production rate of FT4 decreases (v0 = 0.0004–1), FT4 decreases while TSH increases, with the curve displaying a non-linear relationship between the two hormones. The points were measured in hypothyroid patients (different colour by patient id) post thyroidectomy prior to radioiodine treatment before commencing LT4 treatment.
Mar 16, 2023, 06:31 · · 1 · 1
stofskiftesygdom @stofskiftesygdom@home.social

I collect knowledge about metabolic disease and publish it on http://stofskiftesygdom.dk
Jeg samler viden om stofskiftesygdom og udgiver det på http://stofskiftesygdom.dk #fedi22 #hypothyroidism, #hypothyroid, #thyroid, #T3, #T4, #FT3, # FT4, #TSH

stofskiftesygdom.dk

tanker om stofskiftebehandling

stofskiftesygdom.dk
Dec 08, 2022, 11:09 · · 0 · 0
stofskiftesygdom @stofskiftesygdom@home.social

https://www.mdpi.com/1924770 yet another reason to test FT3 #FT3/FT4

Low FT3/FT4 Ratio Is Linked to Poor Prognosis of Acute Myocardial Infarction in Euthyroid Patients with Type 2 Diabetes Mellitus

This is an observational, retrospective, single-center…

www.mdpi.com
Nov 12, 2022, 11:50 · · 0 · 0

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