Johannes W. Dietrich @drjwdietrich@qoto.org
- Sektion DES / Klinik
- http://www.endokrinologie.org
apl. Prof. Dr. med. Johannes Dietrich, endocrinologist, head of the diabetes, endocrinology and metabolism section of #KKB @RUBMedizin. Views are my own.
Joined Nov 2022
Johannes W. Dietrich
boosted
Mediterranean diet leads to a reduced workload of pancreatic beta-cells, as measured by their secretory capacity #SPINA-GBeta.
https://pubmed.ncbi.nlm.nih.gov/42124052/
https://doi.org/10.3390/nu18091453
https://www.livivo.de/doc/M42124052
Wiley sent us a note that our paper defining the static disposition index #SPINA-DI is among the top-viewed articles of the Journal of Diabetes.
https://pubmed.ncbi.nlm.nih.gov/38169110/
https://doi.org/10.1111/1753-0407.13525
https://www.livivo.de/doc/M38169110
Johannes W. Dietrich
boosted
Another study highlights advantages of SPINA-GBeta over the #HOMA method, here with correlation to the adherence of #mediterranean diet.
#SPINA_Carb #SPINA-GBeta #SPINA-GR #SPINA-DI
Johannes W. Dietrich
boosted
In an adjusted model, #SPINA_GD correlates significantly with type 2 allostatic load. It parallels the association to central markers of thyroid homeostasis, underscoring the TSH-T3 feedforward control.
https://pubmed.ncbi.nlm.nih.gov/41941533/
https://doi.org/10.1080/10253890.2026.2653858
Ich weiß ja nicht, wer mich vorgeschlagen hat, aber ich bin ab sofort im (ursprünglich 1925 begründeten) Kürschnerschen Deutschen Gelehrtenkalender aufgeführt. Nicht allzu wichtig, aber ganz nett 😅. Ob man aber für die 4 Bände über 1000 € ausgeben möchte...?
https://www.degruyterbrill.com/document/isbn/9783111635460/html
Die politischen Rahmenbedingungen der präventiven Medizin sind in Deutschland unzureichend. Zusammen mit anderen Europäischen Ländern ist Deutschland Schlusslicht in der #Prävention. Das führt dazu, dass die Kosten hoch sind, aber die Lebenserwartung niedrig.
https://blog.endokrinologie.net/politische-rahmenbedingungen-der-praeventiven-medizin-6001/
Mathematical modelling, computer #simulation, and machine learning upgrade #endocrinology. Applying principles of #biocybernetics and #biophysics, they enjoy growing interest and deliver novel methods for research, diagnosis, and therapy.
https://pubmed.ncbi.nlm.nih.gov/41852474/
https://doi.org/10.3389/fendo.2026.1806508
Johannes W. Dietrich
boosted
#SimulAdren, based on #CyberUnits Bricks, has been upgraded to version 1.3 (Green Lizard). This version introduces functionality to save plots and the block diagram of the information processing structure as graphics files.
https://simuladren.sourceforge.io/
https://doi.org/10.5281/zenodo.16324703
https://doi.org/10.5281/zenodo.19010509
Johannes W. Dietrich
boosted
#Trndi is a #glucose monitoring application written in #Object_Pascal. It fetches interstitial sugar readings from continuous glucose monitors (CGM) via different APIs and shows them on the desktop. It also presents a trend over time, colouring, and JavaScript extensions.
Johannes W. Dietrich
boosted
The #Lazarus_IDE for #Free_Pascal has been updated to version 4.6, fixing bugs and updating localisations.
www.lazarus-ide.org
#MCT8 Deficiency, or Allan-Herndon-Dudley syndrome, is a rare severe disorder of #thyroid hormone transport. In our newest paper, we review the state of the art on pathophysiology, diagnosis & treatment.
https://pubmed.ncbi.nlm.nih.gov/41508830/
https://doi.org/10.1210/clinem/dgaf707
https://www.livivo.de/doc/M41508830
Systems modelling explains: A #cybernetic theory of the molecular processes in #COVID-19 predicts oscillatory #inflammation and virus load in severe forms, which result from increased #TMPRSS2 expression.
Severe #COVID-19 is a life-threatening condition, sometimes requiring #ECMO (extracorporeal membrane oxygenation) therapy. In one of our studies, we found that oscillatory inflammation heralds a poor prognosis.
https://pubmed.ncbi.nlm.nih.gov/36991018/
Die #Leibniz-Sozietät der Wissenschaften hat unser neues Buch zur #Hypothyreose auf ihrer Homepage hervorgehoben.
https://leibnizsozietaet.de/neue-publikation-unseres-mitglieds-johannes-w-dietrich/
#Endocrine feedback loops belong to the important foundations of life. However, consistent underlying rules are still lacking. Now, Moriya Raz, Uri Alon, and co-authors describe 5 classes of control circles.
https://www.livivo.de/doc/M41271754
https://pubmed.ncbi.nlm.nih.gov/41271754/
https://doi.org/10.1038/s41467-025-65924-4
#Takotsubo syndrome is a dangerous stress-related #heart disease. Since #T3 upregulates β-receptors, we assumed a link to #thyroid homeostasis. With machine learning, we identified interesting allostatic patterns.
https://www.livivo.de/doc/M33179374
https://pubmed.ncbi.nlm.nih.gov/33179374/
https://doi.org/10.1111/joim.13189
Johannes W. Dietrich
boosted
#SimulAdren has been released in version 1.1. This cross-platform simulator of the corticotropic feedback loop (hypothalamus-pituitary-adrenal or #HPA axis) is based on the #CyberUnits Bricks class library.
https://doi.org/10.5281/zenodo.16324703
https://doi.org/10.5281/zenodo.17924621
https://simuladren.sf.net
Therapy with #TRIAC, a non-classical #thyroid hormone, relieves peripheral #thyrotoxicosis and hypermetabolism in patients with resistance to thyroid hormone β (RTHβ).
https://pubmed.ncbi.nlm.nih.gov/41131705/
Systems Endocrinology: Shaping a new medical discipline with Object Pascal
#Pascal programming
#Systems_Endocrinology
#P4_Endocrinology
#Systems_Medicine
- Sektion DES / Klinik
- http://www.endokrinologie.org
apl. Prof. Dr. med. Johannes Dietrich, endocrinologist, head of the diabetes, endocrinology and metabolism section of #KKB @RUBMedizin. Views are my own.
Joined Nov 2022
