Johannes W. Dietrich @drjwdietrich@qoto.org

Systems Endocrinology: Shaping a new medical discipline with Object Pascal

#Pascal programming
#Systems_Endocrinology
#P4_Endocrinology
#Systems_Medicine

https://youtu.be/RZ9iu_jaAcg?si=Q3m4dHCwfGlq9vd3

There is an ongoing debate in #endocrinology about whether to treat #hypothyroidism with L-T4 alone or a combination therapy with L-T4 and L-T3. But what about patients’ preferences? The majority would choose the combination therapy, as shown in a meta-analysis.

https://pubmed.ncbi.nlm.nih.gov/39290156/

Die Veranstaltung ist am 3. September 2025, 16:30 Uhr bis 19:00 Uhr.

Ort: Hörsaaltrakt der Universitätsklinik St. Josef-Hospital Bochum

https://maps.apple.com/?address=Gudrunstraße%2056,%2044791%20Bochum,%20Deutschland&auid=10703767065566771530&ll=51.492381,7.229894&lsp=9902&q=St.%20Josef-Hospital

Einladung zur 3. Endokrinologischen Abendsprechstunde: Up-to-date Schilddrüse 2025

Von der #Kinderendokrinologie über #Schilddrüse und #Nebenschilddrüse bis zur Arbeit einer Selbsthilfegruppe in der #Endokrinologie

https://www.sci.events/e_180/uptodatesd25/

Patients with #hypothyroidism, even when treated with levothyroxine (L-T4), face increased risk of #dementia and #fatality. Fortunately, the risk can be lowered again by a combination therapy with L-T4 and L-T3, as shown by a recent study.

https://pubmed.ncbi.nlm.nih.gov/40579157/

https://doi.org/10.1210/clinem/dgaf367

Freue mich über meine geheime Wahl in die #Leibniz-Sozietät der Wissenschaften zu Berlin.

Mehr Infos:
https://news.rub.de/leute/2025-07-30-auszeichnung-johannes-dietrich-neu-die-leibniz-sozietaet-aufgenommen

#Syndrome_T, i.e. persistent symptoms and reduced #QoL despite normal #TSH concentration, affects 10% of #hypothyroid patients on #levothyroxine. Careful, multimodal and personalised treatment can result in significantly improved outcomes.

#hypothyroidism #thyroid #SORSHOT

https://doi.org/10.1007/978-981-96-3682-2_11

For the diagnosis and management of #hypothyroidism, measuring #TSH (thyrotropin) concentration is necessary, but it isn’t sufficient. Additional #biomarkers help to improve diagnostic power and to identify #endotypes of dysregulation.

https://doi.org/10.1007/978-981-96-3682-2_10

The background of our observation is poorly understood, but others could confirm the findings, e. g. in this case report.

https://www.medcentral.com/pain/crps/complex-regional-pain-syndrome-induced-hyperparathyroidism-case-study

Complex regional pain syndrome (CRPS) goes along with secondary #hyperparathyroidism. Our group was the first to describe this. The mechanism leading to #sHPT is unclear, but it may contribute to the loss of bone substance in #CRPS.

https://pubmed.ncbi.nlm.nih.gov/30747906/

https://doi.org/10.1097/j.pain.0000000000001520

The interaction of three hormones, #TSH, #T4 and #T3, lays the foundation for #thyroid #homeostasis and its #allostatic responses.

It is necessary to forgo a univariable sight and to consider the evolution of the multihormonal working point to understand health and disease.

https://doi.org/10.1007/978-981-96-3682-2_6

Multiple feedforward motifs and feedback loops maintain #thyroid #homeostasis and #allostasis. The mechanism of relational stability maintains T3 in a balanced and safe range, even in conditions of declining thyroid function.

https://doi.org/10.1007/978-981-96-3682-2_5

Signalling via #thyroid hormones is more than T3 and T4. It involves 27 molecules based on the thyronine skeleton, 10 transmembrane transporters, 3 deiodinases, 6 receptors, and 4 types of action, unfolding a complex firework of possibilities, explaining health and disease.

https://doi.org/10.1007/978-981-96-3682-2_3

Our book is now available in printed form. Use the code SPRAUT to get a discount of 20% at Springer Nature.

http://link.springer.com/book/9789819636822

Relational stability is a major motif of the intertwined feedback loops of #thyroid #homeostasis. The integrated systemic roles and interdependent homeostatically regulated equilibrium of TSH, FT4 and #deiodinase​s maintains appropriate FT3 concentrations.

https://doi.org/10.1007/978-981-96-3682-2_2