There is an ongoing debate in #endocrinology about whether to treat #hypothyroidism with L-T4 alone or a combination therapy with L-T4 and L-T3. But what about patients’ preferences? The majority would choose the combination therapy, as shown in a meta-analysis.
Die Veranstaltung ist am 3. September 2025, 16:30 Uhr bis 19:00 Uhr.
Ort: Hörsaaltrakt der Universitätsklinik St. Josef-Hospital Bochum
Einladung zur 3. Endokrinologischen Abendsprechstunde: Up-to-date Schilddrüse 2025
Von der #Kinderendokrinologie über #Schilddrüse und #Nebenschilddrüse bis zur Arbeit einer Selbsthilfegruppe in der #Endokrinologie
Patients with #hypothyroidism, even when treated with levothyroxine (L-T4), face increased risk of #dementia and #fatality. Fortunately, the risk can be lowered again by a combination therapy with L-T4 and L-T3, as shown by a recent study.
Freue mich über meine geheime Wahl in die #Leibniz-Sozietät der Wissenschaften zu Berlin.
Mehr Infos:
https://news.rub.de/leute/2025-07-30-auszeichnung-johannes-dietrich-neu-die-leibniz-sozietaet-aufgenommen
#Syndrome_T, i.e. persistent symptoms and reduced #QoL despite normal #TSH concentration, affects 10% of #hypothyroid patients on #levothyroxine. Careful, multimodal and personalised treatment can result in significantly improved outcomes.
For the diagnosis and management of #hypothyroidism, measuring #TSH (thyrotropin) concentration is necessary, but it isn’t sufficient. Additional #biomarkers help to improve diagnostic power and to identify #endotypes of dysregulation.
SPINA Carb 5.1.0 Cyclone has been released in its final version.
#SPINA_GBeta #SPINA_GR #SPINA_-DI #SPINA_Carb #insulin #glucose #homeostasis #prediabetes #diabetes
https://sourceforge.net/projects/spina/files/SPINA%20Carb/
The background of our observation is poorly understood, but others could confirm the findings, e. g. in this case report.
Complex regional pain syndrome (CRPS) goes along with secondary #hyperparathyroidism. Our group was the first to describe this. The mechanism leading to #sHPT is unclear, but it may contribute to the loss of bone substance in #CRPS.
The interaction of three hormones, #TSH, #T4 and #T3, lays the foundation for #thyroid #homeostasis and its #allostatic responses.
It is necessary to forgo a univariable sight and to consider the evolution of the multihormonal working point to understand health and disease.
Release candidate 3 for the software SPINA Carb Cyclone is available for macOS, Windows and Linux.
https://sourceforge.net/projects/spina/files/SPINA%20Carb/
https://doi.org/10.5281/zenodo.15249620
Multiple feedforward motifs and feedback loops maintain #thyroid #homeostasis and #allostasis. The mechanism of relational stability maintains T3 in a balanced and safe range, even in conditions of declining thyroid function.
Signalling via #thyroid hormones is more than T3 and T4. It involves 27 molecules based on the thyronine skeleton, 10 transmembrane transporters, 3 deiodinases, 6 receptors, and 4 types of action, unfolding a complex firework of possibilities, explaining health and disease.
Our book is now available in printed form. Use the code SPRAUT to get a discount of 20% at Springer Nature.
Relational stability is a major motif of the intertwined feedback loops of #thyroid #homeostasis. The integrated systemic roles and interdependent homeostatically regulated equilibrium of TSH, FT4 and #deiodinases maintains appropriate FT3 concentrations.
Our eBook on #hypothyroidism has been published. The new cybernetic theory presented here summarises our scientific work of more than 20 years and lays the foundation for improved diagnosis and therapy of #thyroid disorders.
The book is available in EPUB and PDF formats.
Eine #Ketoazidose ist eine gefürchtete Komplikation eines #Diabetes mellitus. Weniger bekannt ist, dass auch andere endokrine Erkrankungen zu einer Ketoazidose führen können. In unserem neuesten Paper stellen wir eine besondere Ursache vor.
https://pubmed.ncbi.nlm.nih.gov/40388982/
https://doi.org/10.1055/a-2540-9824
Release candidate 2 of #SPINA_Carb is available for testing.
https://sourceforge.net/projects/spina/files/
apl. Prof. Dr. med. Johannes Dietrich, endocrinologist, head of the diabetes, endocrinology and metabolism section of #KKB @RUBMedizin. Views are my own.