@Co_Biologists

Early-career researchers

Apply by Friday 2 May for a funded place at our Workshop 'Decoding whole genome doubling: Insights from evolution, development and disease' organised by Renata Basto and Zuzana Storchova.

biologists.com/workshops/decod

#Workshop #Biology #Research #Collaboration #Connections #Networking #Genome #Evolution #Development #Disease #Polyploidy

GenomeBiolEvol

Coppage et al. identify four ancient polyploidy events with unusually high duplicate gene retention. Elevated gene conversion and delayed diploidization suggest a distinct class of paleopolyploid genomes.

🔗 doi.org/10.1093/gbe/evaf054

#NewPaperAlert #genomics #polyploidy #evolution

Laura Buttitta

While we were examining cell cycle dynamics in the male accessory gland, we noticed dynamic cell cycles also taking place in the neighboring maturing Ejaculatory Duct. This work is the result of our investigation into this less well-characterized tissue, essential for reproduction. Please share with those interested in #polyploidy, and #cell cycle responses to #hormonal signaling.

Laura Buttitta

Interesting paper. They see different DNA repair strategies in postmitotic neurons and induction of cell cycle genes in neurons with Cas9 induced DSBs. This is consistent with our work that DNA damage may influence cell cycle gene expression and #polyploidy in the 🪰brain. (Nandakumar et al 2020). Still so much to be worked out. Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes | bioRxiv

biorxiv.org/content/10.1101/20

Neuronal DNA repair reveals strategies to influence CRISPR editing outcomes

Genome editing is poised to revolutionize treatment…

www.biorxiv.org
Nicolas Bierne

Still open PhD position
#Job #phd #Evolution #Genomics #Cancer #TransCan #MarBiol #Polyploidy #PopGen #France
Here is an offer for a PhD (ERC HYPERCAN project) on the evolution of a transmissible cancer, with a focus on hyperploidy variations:
euraxess.ec.europa.eu/jobs/230401
Please boost

Mike Barker

A new preprint from the lab on the distribution of ancient whole-genome duplications across the angiosperm phylogeny. Great work led by PhD student Michael McKibben! We used a variety of methods and different species trees to infer and place WGDs across the phylogeny. Overall, similar results to our past work, but species tree had a large impact on WGD inferences. Check it out here:

biorxiv.org/content/10.1101/20

#WGD #polyploidy #phylogeny #angiosperms

Luis M. Rocha

I am fascinated by the recent evidence showing that Polyplody may grant evolutionary advantages in the presence of drastic fitness changes (e.g. cataclysms):
science.org/content/article/ce.

One option is that extra chromosomes may increase connectivity of gene regulatory networks--- fascinating work from van de Peer on that note: doi.org/10.1101/2023.04.28.538, doi.org/10.1371/journal.pone.0.

The results are similar to ours a long time ago with RNA Editing , where we experimented with drastic fitness changes (simulated cataclysms) and emergence of memory: doi.org/10.1162/evco.2007.15.3, doi.org/10.1007/978-3-540-7491.

RNA Editing, we started arguing long ago, also adds additional regulatory variety and proves advantageous in drastic fitness changes---though RNA editing works by adding more variants, not greater number of regulatory possibilities (network connectivity) as it is hypothesized for polyploidy. Maybe this explains why the latter is maladaptive in stable fitness landscapes, whereas RNA Editing often isn't?

#Evolution #EvolutionarySystems #Polyploidy #Fitness #GenomeComplexity #Gemome

Laura Buttitta

@ScienceMagazine Polyploidy is far more common in animals than many people realize. For those interested in looking at the variety of cell types that are #polyploid across species please check out our #Polyploidy Atlas : www.polyploidy.dev

Tyler Smith

New from my lab: Allopolyploid plants do not occupy larger ranges or harsher conditions compared with their progenitors

onlinelibrary.wiley.com/doi/10

The idea that polyploids occupy harsher environments than diploids was proposed nearly century ago, and is now widely accepted. However, the data supporting this idea is very limited, and there are many examples of studies showing contrasting results.

We developed a dataset of 123 polyploids with known diploid progenitors, and show that there is no support for the hypothesis that the polyploids have larger or more extreme ranges than the diploids.

#Polyploidy certainly has a strong impact on #evolution, but it's clearly complex and context dependent. Not something so general and straightforward as 'polyploids tolerate broader conditions, and so have bigger ranges'.

Alex_Kiryushkin

What do we have here?

The plant ploidy database.

by Keren Halabi, Anat Shafir and Itay Mayrose (Dept. of Molecular Biology and Ecology of Plants at Tel Aviv Uni; tau.ac.il/~itaymay/).

fresh in New Phytologist

Article👉shorturl.at/jnBXZ
DataBase👉ploidb.tau.ac.il/
#polyploidy #plants #genomics