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New paper from the Zerial Lab!
My colleagues and I have shown that apical projections across the bile canaliculi are load-bearing structures. These structures contribute to sustaining the anisotropic #growth of the nascent tube under increased intraluminal #pressure during #liver #development. These structures are supported by adherens #junctions and sealed by tight junctions.
I believe only @nunopmartins is here but if I am mistaken please tag any other author.
#CellPolarity #CellBiology #actomyosin #tubulogenesis
Bebelman and Bovyn et al. demonstrate that apical bulkheads,…
rupress.orgTopics include #liver, #lung and #kidney #fibrosis, #cancer #metastasis, #inflammation, #cardiovascular #disease, #development, #neuropathology, #proteoglycans, #cell #junctions, #sphingolipids, #tissue #clearing, and more!