@cmclase @LaurieTomlinson on RASi - what I find fascinating is data from the COVID RAS studies, eg BRACE CORONA, REPLACE COVID @jordy_bc - and soon CLARITY
None of them show benefit of course, but it’s 🤯that continuing RASi in hospitalized COVID, or even starting RASi (CLARITY) didn’t cause harm.
We should really rethink sick day rules!

@hswapnil @LaurieTomlinson @jordy_bc

Yes and thank you for all those refs - will incorporate!

Thinking for need a rethink!

@jordy_bc @cmclase @LaurieTomlinson since I am on a roll 😎
What about flozins?
Yes you can see euglycemic DKA in a small number, but
- EMPULSE shows benefit starting with acute decompensated HF nature.com/articles/s41591-021
- DARE showed no harm starting DAPA in peeps hospitalized with COVID

It’s not stop flozins for all when sick - we need nuanced guidance🤔

@cmclase @LaurieTomlinson @jordy_bc @hswapnil This is the way. The question is not how early benefit accrues from SGLT2i (or RASi) but when it is safe to start. I’ m a critical care #flozinator😅

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@load_dependent @LaurieTomlinson @jordy_bc @hswapnil
Maybe the rule is: stop when fasting. Any info on 12-18h fasts as in Ramadan or intermittent fasting?

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