"Here, we show that neuronal signal-regulatory protein alpha (SIRPα) is a permissive cue for microglial #phagocytosis in the developing murine retina. Removal of neuronal, but not microglial, SIRPα reduced microglial phagocytosis, increased synpase numbers, and impaired circuit function. Conversely, prolonging neuronal SIRPα expression extended developmental microglial phagocytosis. These outcomes depended on the interaction of presynaptic SIRPα with postsynaptic CD47."

#Immunity #Immunology #Microglia #Neuroimmunology

https://www.cell.com/immunity/fulltext/S1074-7613(22)00559-3