"We found that TCR signal intensity coupled STING signal strength to the unfolded protein response (UPR) and T cell survival. Under strong STING signaling, Indoleamine-pyrrole 2,3-dioxygenase (IDO) inhibition also reduced apoptosis and led to a recovery of T cell memory in STING sufficient CD8 T cells."

#Immunology #STING #Tcells
#ImmunologicalMemory

https://www.pnas.org/doi/10.1073/pnas.2205049120