'For example, loss of function of the microglial gene Trem2 renders microglia dysfunctional and causes an early-onset neurodegenerative syndrome, and Trem2 variants are among the strongest genetic risk factors for AD. Thus, restoring microglial function represents a rational therapeutic approach. Here, we show that systemic hematopoietic cell transplantation followed by enhancement of microglia replacement restores microglial function in a Trem2 mutant mouse model of AD.'

#Alzheimer #NeurodegenerativeDisease #Microglia #Neuroimmunology

https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00251-5#%20