"Inflammasome-mediated caspase-1 activation facilitates innate immune control of Plasmodium in the liver, thereby limiting the incidence and severity of clinical malaria. However, caspase-1 processing occurs incompletely in both mouse and human hepatocytes and precludes the generation of mature IL-1β or IL-18, unlike in other cells. Why this is so or how it impacts Plasmodium control in the liver has remained unknown."
#Malaria #inflammasome

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300440/266573/Inherently-Reduced-Expression-of-ASC-Restricts?redirectedFrom=fulltext