Mechanisms of metastasis.
'Together, our data show that glucocorticoids released during chronic stress cause NET formation and establish a metastasis-promoting microenvironment. Therefore, NETs could be targets for preventing metastatic recurrence in cancer patients, many of whom will experience chronic stress due to their disease.'
#Cancer #Neutrophils #Metastasis #Immunology
https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00037-0?
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Mikala Egeblad discussed some of this work at a workshop in Les Treilles last spring, organised by Tasuku Honjo & Antonio Coutinho. Here's a meeting report I wrote 👇 (the abstract is in French, but the rest of the text is in English).
