'We found that up-regulation of a primate-specific short isoform of PRDM1-S induces expression of SGK1 independent from the evolutionarily conserved long PRDM1, which led to destabilization of #FOXP3 & #Treg dysfunction. This aberrant PRDM1-S/SGK1 axis is shared among other autoimmune diseases.'
#Immunology
https://www.science.org/doi/10.1126/scitranslmed.adp1720