@freemo depends. There are certain times it can be an obstacle. For example, the undo/cut/copy/paste commands are now scattered across the keyboard. Some software that uses keys based on position rather than letter value (e.g. WASD keys if you're a gamer) works automatically, some needs to be configured, and some just leaves you stuck with unusable keybinds. Importantly, early in your boot process (BIOS password, disk encryption) you'll still have to type in QWERTY because the computer doesn't know anything about your keyboard settings until after you've decrypted that information.

It will restrict your options for customising your keyboard, because many keycap sets have different profiles on a per-row basis, so keys that are in a different row between QWERTY and Dvorak will stick out. Obviously you'll touch-type most of the time, but sometimes you run into situations where you have one hand on the keyboard and one on the mouse, and you'll need to find a key with your left hand for which only your right hand has muscle memory.

Also, if you swipe-type on your phone, some of Dvorak's strengths become weaknesses. Alternating fingers turns into a lot of back-and-forth. Concentrating heavily used keys onto the homerow means you have to be very precise, and even then there are a lot of ambiguous words. For example, swiping S-O-T could be:
- soot
- snot
- snout
- stout
- shot
- shoot
- shout
and that's if you aim perfectly. If you miss by one key and type S-E-T there's a whole different set of words. The poor autocorrect can only do so much for you.