Thomas Pradeu @pradeu@qoto.org

Resurrection of endogenous retroviruses during aging reinforces senescence

https://www.cell.com/cell/fulltext/S0092-8674(22)01530-6

🦟 By targeting #bonemarrow, @MattMartiLab's team @UofGlasgow hope to block a deadly parasite’s ability to transmit #malaria – an important step towards developing drugs and #vaccines that could eventually eradicate the disease.

👉 https://bit.ly/3uS0zRh

@CORDIS_EU #mosquito

🐦🔗: https://n.respublicae.eu/ERC_Research/status/1607307747770642433

Fission is in the news, but few recognize that a woman physicist was behind the discovery.

Lise Meitner’s brilliance led to the discovery of nuclear fission. But her long time collaborator Otto Hahn, was awarded the Nobel Prize in Chemistry w/o her in 1944, even though she had given the first theoretical explanation.

Albert Einstein called Meitner “our Marie Curie." She also adamantly refused to work on the atomic bomb during WWII. https://www.aps.org/publications/apsnews/201502/physicshistory.cfm #women #history #science #energy

"In this work, we explored possibility of using drug-sensitivity data together with basal gene expression data on pancreatic cell lines to predict the combinatorial options available for HDACi and developed bioinformatics screening protocol for predictions of synergistic drug combinations in PDAC. "

#Preprint #PDAC #HDAC

https://www.biorxiv.org/content/10.1101/2022.10.10.511584v3

The historic MBL Physiology Course is now accepting applications! If you're interested in learning more about the course and the application process, be sure to join us on Friday, January 13 at 9 AM PT for a virtual open house (https://berkeley.zoom.us/meeting/register/tJIlc-6gpjgjEt3OkOiHp6MCLgLm1HQiPOX6).

More info about the course is available here: https://www.mbl.edu/education/advanced-research-training-courses/course-offerings/physiology-modern-cell-biology-using-microscopic-biochemical-and-computational-approaches

Excited to share my first post on this platform for #MicroscopyMonday. #microscopy #villi #intestine #gut

It's hard to know where to start with references to the correlation vs. causation problem in scientific publication. There's obviously an absolutely massive literature on causal inference that gets at how to draw this distinction.

As for abuses in the published literature, there are a number of metaresearch papers on this as well. In particular, @noahhaber has written extensively on this.

For starters:

https://pubmed.ncbi.nlm.nih.gov/21196788/

https://pubmed.ncbi.nlm.nih.gov/29847549/

https://pubmed.ncbi.nlm.nih.gov/35925053/

Some belated #introduction:

I'm a philosopher of science, in particular cognitive (neuro)science, computation and information. Here's my book: https://mitpress.mit.edu/9780262018869/explaining-the-computational-mind/

My second field is #nlp: see LanguageTool (https://www.languagetool.org), a style and grammar checker for many natural languages (I have developed the rule set for Polish).

Associate Prof at the Institute of Philosophy and Sociology, Polish Academy of Sciences. I chair the Section for Logic and Cognitive Science.

Just updated my website to better reflect the activities of my lab. What we're doing is cognitive metascience: cognitive research on how scientists reflect upon their own scientific practice. https://marcinmilkowski.pl/cognitive-metascience/

I've literally taught grad level seminars on selection bias and yet spent a non-trivial amount of time this evening wondering "why are conspiracy theorists so bad at doing their research?"

#introduction Hi All. I am @tisimpson on Twitter, just starting on here.

I'm interested in the application of computational/statistical methods to biomedical areas. Much of our work involves using multi-modal data: #genomic, #clinical, and #molecular to better understand neurological disease of genetic origin.

We develop and use a lot of #network, #dataintegration, #statistics, and #machinelearning approaches in our research.

Postdoctoral Research Position in the Mi lab at Yale University @weimi11

Dr. Wei Mi's laboratory at Yale is looking for a postdoc with background in bacterial genetics, fluorescent microscopy, or structural biology.

https://jobrxiv.org/job/yale-university-27778-postdoctoral-research-position-in-the-mi-lab-at-yale-university/?feed_id=32766
#Scien...
https://jobrxiv.org/job/yale-university-27778-postdoctoral-research-position-in-the-mi-lab-at-yale-university/?feed_id=32766

Exciting to have the next phase of #UCCFutures launched.

UCC Futures: Food, Microbiome & Health builds on our long history of groundbreaking research in food, nutrition, health & microbiome science

Recruiting 14 academic posts!

'But the authors are particularly set off by the habit of referring to the unfolded state as some sort of unique form common to most proteins, whether this unfolding is done by excess heat, lack of heat, pressure changes, chemical means, or whatever.

I can see their point. This is an example of “reification”, the philosophical mistake of “turning something into a thing” when it isn’t actually a separate entity or even a real one.'

cc @pradeu

https://www.science.org/content/blog-post/unfolding-unfolded

From Kevin Foster and collaborators

"The order and identity of incoming symbionts is critical for health, but what determines the success of the assembly process remains poorly understood. Here we develop ecological theory to identify factors important for microbial community assembly. Our method maps out all feasible pathways for the assembly of a given microbiome—with analogies to the mutational maps underlying fitness landscapes in evolutionary biology."

#Microbiology #MucosalImmunology

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001116

Really excited to launch @Dev_journal@twitter.com "Pathway to Independence Programme"

Are you, or do you know, a dev bio or stem cell researcher planning to apply for their 1st PI position in 2023?

Then this scheme is for you. See how to apply:

https://journals.biologists.com/dev/article/149/23/dev201456/285866/The-Pathway-to-Independence-programme-helping