(1/3) Neuronal reactivation and replay in the #hippocampus is important for #learning and #memory. So does reactivation induce or modulate synaptic plasticity? We think it does! This is a video abstract made with #blender of our recent paper in #elife.
For higher quality video watch https://www.youtube.com/watch?v=v93Ci-koiNY
(3/3) Based on this finding we formulated a new learning rule and found that it adds specificity to reinforcement learning by controlling memory allocation in the #network.
@tanjafuchsberger What a fantastic video: great way to explain the key findings of a paper, and to do so artistically and beautifully.
@albertcardona Thanks, Albert, very happy you enjoyed the video. Blender really is an amazing tool providing a wide range of possibilities for all sorts of scicomm!
@tanjafuchsberger
Beautiful video! In N accumbens, DA is permissive and a signal from amygdala drives reward firing (cf Ambroggi et al Neuron 2008). Is there an amygdala signal driving a coincident signal here, or do you think the DA pulse downstream of that circuit (via amyg->VTA) carries info that the reward was found?
@brendonowicz Thanks! Excellent question.. If that input from the amygdala (via direct or indirect connections) triggers an action potential burst, and DA is present then this could trigger this type of plasticity. We have shown it only for the hippocampus, but it may well also work like that in other brain areas..
@tanjafuchsberger
Extremely cool video and great explanation! Can't wait to read the paper. Congrats!
@tanjafuchsberger Such a cool video! I really want to learn Blender to do things like this. I think it’s a great tool for science communication!
@neurrito Thanks! Using Blender really opens up a whole new range of possibilities for scicom. When I started using it I had no experience with 3D animation. It took a few weekends to get into it, but def worth the effort, it's so much fun!
(2/3) The video abstract shows what we think happens (rather than how it happens). We found that burst + dopamine acts on a molecular coincidence
detector AC1/8. To find out more about the underlying signalling pathway please read our paper
https://elifesciences.org/articles/81071