Hao Yin @HaoYin@qoto.org
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op
Joined Nov 2022
Hao Yin
boosted
Ooh another really interesting paper on #alzheimers and #lactadherin
Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease
Phospholipase Cε #Aortopathy
Plce1 KO🐭 are susceptible to ANGII-induced ascending #AorticAneurysm+Dissection
Role of adventitial myofibroblast cytokines?😎
Dr. Alan Smrcka, Santhi Ganesh, Markus Bitzer labs AJP Heart Circ 2022
https://journals.physiology.org/doi/abs/10.1152/ajpheart.00262.2022
Hao Yin
boosted
A new #SpatialTranscriptomics technique was published on Cell! The authors used polony gels to capture the RNA in situ, and used pixel-seq to map #singlecell transcriptomes back to the tissue. Amazing experimental design! https://www.cell.com/cell/fulltext/S0092-8674(22)01367-8
Hao Yin
boosted
BulkSignalR, a R package to infer ligand-receptor networks from bulk data including Visium #rstat #RNAseq #SpatialTranscriptomics
https://www.biorxiv.org/content/10.1101/2022.11.17.516911v1
Hao Yin
boosted
scFates: a python package for pseudotime analysis from single cell data #scRNAseq #scATACseq #bioinformatics #python
https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btac746/6832042
Kidney epithelial #Tubuloid
CD24+ epithelial progenitor-derived
4-phase protocol, Matrigel +Wnt3a/RSPO1, grow > 6 mo
CRISPR modeling #ADPKD, Cyst size responsive to #Tolvaptan
Super-impressive single-cell or single-nuclei RNAseq analyses to dissect the spatiotemporal molecular/cellular dynamics of this cool renal tubuloid, laying a critical foundation to enhance its clinical utilities👍
Wonderful #Lumenogenesis of CD24+ epithelial progenitor-derived nephrospheres, day 7 in Matrigel🤠
Dr. Rafael Kramann lab @NatureGenet 2022 @jackxuyx @KuppeChristoph @rkramann
https://www.nature.com/articles/s41588-022-01202-z
Hao Yin
boosted
Welcome @karinayaniv ! I’m also just testing the waters here. I like it :) Slowly but surely finding all ours friends and colleagues! #science
Editing a gateway for #CellTherapy across #BloodBrainBarrier
An excellent review🤠 Learn a lot!
Lesson from Leukocyte-#BBB interaction->
Engineering strategies->
⏫Cell delivery to injured🧠#Stroke
Dr. Rust Ruslan lab Brain 2022
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awac393/6832391
Hao Yin
boosted
#EndothelialCell MEK1 #VascularMalformation
P1 topical 4OHT-induced mosaic EC MEK1 K57N transgene (what is the efficiency🧐)->
50% death by P30 +multiorgan VM (Arteriovenous malformation or other lesions) & Hemorrhage
Lesions composed of both mutant & WT EC
Dr. Patrick Smits lab Angiogenesis 2022
https://link.springer.com/article/10.1007/s10456-022-09853-6
Hao Yin
boosted
The latest from the lab spearheaded by @vijaykrishnarag: Cell derived matrices from bovine corneal endothelial cells as a model to study cellular dysfunction. #ophthalmology #cornea @nationaleyeinstitute https://www.sciencedirect.com/science/article/abs/pii/S0014483522003840?via%3Dihub
Hao Yin
boosted
Hi everyone👋 #preLights is a #preprint highlights service run by the biological #community and supported by #Co_Biologists allowing researchers to:
🔎 Sift through the growing volume of preprints.
💡 Highlight new thinking or new techniques across the biological sciences.
📝 Comment on preprints that are of particular interest.
👥 See comments and opinions of other researchers.
Toots from Reinier Prosée, the preLights community manager.
12q, an optimized small chemical activator of #Sirt6
Comprehensive analyses vs MDL-800->
⏫Sirt6 deacetylase & demyristoylase activities
⏫Anti-#PancreaticDuctalAdenoCarcinoma activity
Look forward to more studies on its Non-tumoral benefits?🧐
Dr. Shengyong Yang lab J Med Chem 2022
https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.0c01183
Hao Yin
boosted
After scoping out Mastodon for about a week now, it's probably time for an #introduction
Hi I'm Alex, a Reviews #Editor for @Dev_journal, a community #journal covering #devbio, #stemcells & #regeneration. Development hosts the #devbiol community blog @the_node and is published by the @Co_Biologists.
I'll mostly be tooting about amazing #devbio research and conferences, and occasionally about personal stuff like #books, #reading, #gardening and other adventures on my bike or #kayak.
Hao Yin
boosted
Hi #ScienceMastodon. We, at #Dev_journal, are a #community journal covering #DevBio, #stemcells, #regeneration and more. Development is led by Editor-in-Chief @jamesbriscoe & published by the not-for-profit @Co_Biologists.
We’ll be tooting about our #research papers, #reviews, #interviews, charitable activities, #conferences and #devbiol news from our community site, @the_node.
Toots by Online Editor @helenzsci, Reviews Editor @amjeve & Executive Editor Katherine Brown
Pancreatic Rab11a/Rab11b dKO->
Aberrant polarized transport of apical/basolateral proteins->
AMIS supernumerary->
Defects in ductal #Lumenogenesis; Acinar morphogenesis; Pancreatic cell lineage dysregulation
Highly intriguing, PancRab11KO->⏬Sox9+ bipotent progenitor & #Islet mass-> #GlucoseIntolerance in suvived adult🐭
Lumenized epithelial paracrine or endocrine-autonomous defect?😆
No baseline change in fast glucose. Insulin/glucagon? Adult islet histology-Amyloid degeneration?
The branched, lumenized pancreatic duct is fragmented into disconnected Microlumens + enlarged Cyst in PancRab11KO🐭
Can't help but think Rab35 in anisotropic Lumenogenesis of liver #BileCanaliculi
Is there a primary hydro-osmotic defect here?😋
Still, what happens to pancreatic vascular morphogenesis in Panc-Rab11 KO🐭?(Surely, epithelia & endothelia are coupled🤪)
More importantly, now it's the magic timing if you also want to have such amazing stories
Cleaver lab is recruiting TWO postdocs
Dr. Ondine Cleaver lab @ondinecleaver2022 bioXRiv 2022
https://www.biorxiv.org/content/10.1101/2022.11.17.516976v1
Hao Yin
boosted
Does anybody else find Mastodon to be buggy (slow)? I’m sure it’s the crush of people fleeing the bird site. But wondering if it’s just me.
(Also I realize the servers are maintained by volunteers and not a for-profit company, hence grateful, but curious).
Hao Yin
boosted
Excited to share our preprint on the role of Rab11 in microlumen formation during early pancreas development.
When Rab11 is genetically deleted in pancreatic epithelium:
-intracellular cargo containing apically targeted proteins are stuck in the cell
-Lumens fail
-Branch morphogenesis is defective
-Beta cell mass is reduced
Cool work spearheaded by grad student Haley Barlow. #DevBio #DevBiol #Pancreas #BetaCell #Lumen #SendFeedback
Hao Yin
boosted
The small RNA landscape is stable with age in Drosophila
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0273590
Hao Yin
boosted
🚨JOB ALERT🚨
My lab at University of Maryland-Baltimore is hiring a postdoc!
Consider applying if you are interested in cellular regulators of excitability #ionchannels, mouse brains🧠, CRISPR-Cas9 gene-editing 🧬✂️, and behaviors 🐭
(more info here: https://thejuarezlab.com)!
We are dedicated to the promotion of diversity and inclusivity in science.
We can also connect at #ACNP2022 in December!
#neuroscience #neurojobs #PDjob #URMinSTEM #BlackinNeuro #DSPAN #HHMIGilliam #NeuroMastodon
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op
Joined Nov 2022
