JohnTaylor @JohnTaylor@qoto.org

Some nice work from Ethan Toriki, James Papatzimas, Daniel Nomura and coauthors on bioRxiv https://www.biorxiv.org/content/10.1101/2022.11.04.512693v1

I think this is the first example in the “glue degraders” field where someone found a “degrading handle” that could be attached to multiple different inhibitors to give degradation of different proteins. A nice step forward in the rational design of molecular glue degraders!

#TPD #MedicinalChemistry #degraders

A bit late, but here is my #introduction. I am biologist and a Group Leader @HelmholtzMunich. We study #CellDeath mechanisms and translate these findings into future drugs using #ChemicalBiology and #DrugDiscovery approaches. We are particularly interested in deciphering the cellular mechanisms controlling #Ferroptosis and characterizing regulators of #Ubiquitin Signaling in #CellDeath pathways. In addition, my lab operates the Compound Screening Platform with strong expertise in #HTS and #HCS.

Mentioning this here as well: New(ish) review. Many geometric #deeplearning methods use the 3D structure of macromolecules to predict properties that are relevant for #drugdesign.
Preprint: arxiv.org/abs/2210.11250
Work with @atzkenneth & Gisbert Schneider.
#compchem #machinelearning #drugdiscovery (1/4)

🎉Happy to see our new ChemBioChem work led by Devin Ray out exactly on time for our traditional graduation 1:1 dinner…
Proud of you Devin 😍 & good luck in going back to the clinic!
Stay tuned for the cover🤩
@Ruben

https://onlinelibrary.wiley.com/doi/10.1002/cbic.202200487

Now that I have the opportunity, let me #introduce our quality-diversity #compchem algorithm to Mastadon. It's based on @janhjensen 's generative algorithm. We avoid stagnation issues, and illuminates opportunities across chemical space, and outperforms #deeplearning approaches!

Code: https://github.com/Jonas-Verhellen/Argenomic

Paper: https://pubs.rsc.org/en/content/articlelanding/2020/sc/d0sc03544k

#drugdesign #optimisation #algorithm #chemistry #generative

#introduction time now that I'm ready to start trying mastodon out!

I currently work as a data scientist in the population health realm. Our team supports public health decisions. Previously, I was a research astronomer; my PhD work was on #exoplanets.

I'm a dad to 3 kids, 5 and under, and we live on unceded Snuneymuxw territories.

On Mastodon, I hope to stay in touch with astronomers and meet other cool folks! I'll probably toot about parenting and science.

#astrodon #astronomy

Are you a prospective PhD student excited about Quantitative Biology? If so, Georgia Tech has an amazing interdisciplinary PhD program for you (QBios). Apply to join us by December 1st!

Hi #ChemiVerse

I might come to regret this, but I've seen some journalists compiling lists of people on here & I thought it might be useful in the early days here to do something similar for the chemistry community (& those who interact with the chemistry community – you can define that quite liberally).

So, here is a Google Form that you can fill in if you wish: https://forms.gle/gF9MLUGMWs23EFix6

And it feeds into this Google Sheet: https://docs.google.com/spreadsheets/d/1qdJvHHvu-BC4N6nk1jNMhTwoBrIaqHLUCZRf9pCQwDs/edit?usp=sharing

(The form does not collect e-mail addresses)

Time for that #introduction:

I'm Neil, I'm the features #editor on #ChemistryWorld and I commission, edit and publish the long articles, normally about one a week.

Here's this week's, on the #hormones behind what makes you #hangry
https://www.chemistryworld.com/features/the-brain-chemicals-that-control-what-we-enjoy/4016483.article

Maybe I'll move the #tractors account over later...

#Introduction
Just migrated to a new instance on med-mastodon -

I am an Infectious Diseases physician and Clinical Informaticist in the Chicago area. I have been with Tendo since January 2022, an early stage company in the patient experience space, building out our analytics capability.

I have had research interests over the years in healthcare quality (and the flaws with how it is measured) and use of data in healthcare. #informatics #interoperability #quality #outcomes

#introduction to our work. Trained as an organic chemist, I found my passion for #glycotime working with @bertozzi at stanford university on understanding #raredisease #NGLY1 deficiency during my postdoc. With my team, currently located at Heinrich Heine University in Duessendorf, I use #bioorthogonal chemistry to study aberrant #glycosylation in congenital disorders of glycosylation and some types of cancer. We develop multi-modal chemical probes for #imaging and #glycoproteimics

#introduction
Hi! I'm the Director of Communications at ORCID. If you're in research, you may know of us: we uniquely identify & connect researchers & innovators to their affiliations and contributions across disciplines, borders, and time.

I have a long history in #SciComms. When I'm not doing that, I'm working on my first novel or planning my next concert adventure.

I love ORCID's values of Openness, Trust, and Inclusivity. I'm also keen on kindness & collegiality which is why I'm here. 😀

Hi everyone, I’m new to mastodon and figuring out how to use this new platform. I’m Fleur Ferguson, a chemical biology professor at UC San Diego! My lab uses organic chemistry, cell biology and proteomics to interrogate disease signaling and develop next-gen therapeutics! #ChemicalBiology #targetedproteindegradation #newPI

#introduction

Hi there! My name is Cedric and I'm a synthetic medicinal chemist. I design and develop new molecules hoping to find something useful to treat neglected tropical diseases such as #Malaria, #Leishmaniasis and #Chagas disease.

Currently I am a #MedicinalChemistry trainer at the Wellcome Centre for Anti-Infectives Research at the University of Dundee, Scotland. My interests are #chemistry, #DrugDesign, #compchem and some #python on the side.

Hi #Science #structuralbiology people.

The lab I work in at the Crick has a #PhD studentship available starting Autumn 2023, deadline for application is *Thursday* 10th Nov 12noon GMT

The project involves structural investigation of receptor tyrosine kinase signalling complexes. Main techniques include #CryoEM and #crystallography.

Details here: https://www.crick.ac.uk/careers-study/vacancies/2022-10-05-mcdonald-lab-exploring-multimeric-assemblies-driving-ret-receptor-tyrosine-kinase-activation

Please Boost! #phdchat

Highlighting a new cross-journal Editor's Choice collection celebrating Professor Malika Jeffries-EL joining Chemical Science as an Associate Editor!

Malika has always been excited by chemistries that push the boundaries in the pursuit of complex materials and the optimization of their properties.

The selection features experimental and theoretical work leading to new materials for use in a range of applications.

#chemistry #OrganicElectronics #OrganicSemiconductors

http://ow.ly/UUtA50LvVXQ

I did not introduce myself after setling up in #Mastodon. I am Professor of Chemistry at Sorbonne Université in Paris. Technically, I am a quantum chemist but I learned a while back ago that molecules do move over time...(incredible!). I am therefore interested in Multiscale Quantum Chemistry and Molecular Simulation. My group's research is performed in strong interdisciplinary interactions with Applied #Maths & #HPC.
#compchem #supercomputing #quantumcomputing #machinelearning