Joshua Sharp @JoshuaSharp@qoto.org
- Lab Web Page
- https://massspec.olemiss.edu/
Director, GlyCORE. Analytical and biophysical chemist. Dept. of BioMolecular Sciences, U of Mississippi. Personal account, all opinions my own. Pronouns: he/him
Joined Nov 2022
@RonBeavis How many experimentally confirmed N-linked sites are on MUC16? I know there are quite a few sequons, but my understanding was that the N-glycan content was rather modest.
Joshua Sharp
boosted
So, yeah, if we take these two stories in combination: Elon is (a) demanding that everyone who uses Twitter hand over their live location info to him and (b) has now banned anyone from posting the live location of anyone.
Joshua Sharp
boosted
Place your bets
"To try to prove our own brilliance scientifically (before we are replaced by machine learning) is a challenge few editors would be able to resist, and we were no different. We thus set out to test our ability to predict citations of unpublished research papers submitted to The BMJ."
Joshua Sharp
boosted
Now you know: #Gender composition of #PhD degree earners in 2021: Selected fields with >500 degrees.
#highered @academicchatter
Joshua Sharp
boosted
Joshua Sharp
boosted
Announcing papertooter. Papertooter is a simple script that takes the URL of a biorxiv preprint, and posts the title and link to the paper on Mastodon using the Mastodon Python API. It also posts a unique hashtag it generates from the paper's DOI.
Feature requests and bug reports welcome.
I am thrilled to announce the publication of our most recent paper, which can be found at https://doi.org/10.1021/acs.analchem.2c04365. We couple hydroxyl radical protein footprinting inline with weak anion exchange chromatography to measure the structural changes caused by phosphorylation/dephosphorylation of specific residues in a protein DURING a phosphatase reaction! This work opens up structural analysis of a wide variety of dynamic systems, where a particular conformer or proteoform cannot be isolated for high res structure elucidation. Very proud of this work, and of the group members that made it possible. #TeamMassSpec @strucbio
Joshua Sharp
boosted
What a tragedy that this good man, who has devoted his life to public service, who has made mistakes and learned from them, and who still expresses a profound understand of America’s public-health problems, should remain a target of vitriol from the worst among us. https://www.nature.com/articles/d41586-022-04432-7
Joshua Sharp
boosted
I will have PhD and RA positions open very soon. There's quite some flexibility for young researchers interested in experimental and #bioinformatics approaches in #MassSpectrometry #proteomics and #singlecell.
Please boost and spread. Feel free to get in touch.
Joshua Sharp
boosted
Joshua Sharp
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Out today, my short piece in Nature Medicine about what scientists can do as authors to combat misinformation and disinformation about their own work.
Joshua Sharp
boosted
Notorious lickspittle Lindsey Graham doesn't seem to understand that we don't license expression in this country, and the reason for that is made plain by his suggestion: it would be used to punish expression that upsets the government.
Joshua Sharp
boosted
📜 Our latest collaboration out in @embojournal!
In efforts led by Dr Ben Wang and Dr Julie Takagi, we identify Core 2 glycans as inhibitors of toxigenic conversion by a virulence-encoding phage in Vibrio cholerae.
#GlycoTime
💰 support: @snsf_ch & @UniBasel
https://embopress.org/doi/full/10.15252/embj.2022111562
Joshua Sharp
boosted
@J_mey_sci Hey Jesse, there's a list here you can import as a CSV, or one by one, and some tips too. https://fosstodon.org/@makingions/109311378275759937
Joshua Sharp
boosted
Big day for vaccines? HUGE day for vaccines. https://www.reuters.com/business/healthcare-pharmaceuticals/moderna-merck-vaccine-combo-cut-melanoma-recurrence-by-44-study-2022-12-13/
@neely See, I was gonna put a Kamala Harris "This is serious" gif at the end of my reply, but I couldn't!
@neely They need to integrate gifs into the standard apps and web interface if they want to attract the serious scientists...
Joshua Sharp
boosted
Okay. Migrated from masthead.social to mastodon.social. Meanwhile, here's the Substack on my decision to leave Twitter.
Joshua Sharp
boosted
The toughest thing about proving white collar crime, as I've learned from @Popehat is proving intent. I'd imagine that suspects having a groupchat called "Wirefraud" must make prosecutors positively *giddy*. (ht: @annmlipton ) https://www.afr.com/companies/financial-services/ftx-s-inner-circle-had-a-secret-chat-group-called-wirefraud-20221213-p5c5sx
"The other reason is that I think it’s fundamentally changed, at least for now. I’m not just talking about the increasing tech glitches. Just as Twitter’s former leaders exercised their free speech and free association rights to brand Twitter one way, Twitter’s new boss is exercising his rights to brand it another way. That new branding is ugly and despicable and I don’t want to contribute content to it. The last straw was Elon Musk sending lunatics and bigots against former employees and leaning into conspiracy theories. So I’m exercising my free speech and free association and leaving, and shuttering the account. I’ll probably delete the past tweets because I can’t stomach them being available to promote this enterprise."
--@Popehat
Well said, and ditto. I won't be deleting past tweets right now, but I don't care to associate myself with Twitter anymore. Time for something new.
- Lab Web Page
- https://massspec.olemiss.edu/
Director, GlyCORE. Analytical and biophysical chemist. Dept. of BioMolecular Sciences, U of Mississippi. Personal account, all opinions my own. Pronouns: he/him
Joined Nov 2022
