"Single-molecule magnetic tweezers to capture over a million individual transitions as a single talin protein unfolds and refolds under force in equilibrium. When observed at classically probed timescales, talin folds in an apparently uncomplicated two-state manner. As the sampling time extends from minutes to days, the underlying energy landscape exhibits gradually larger signatures of complexity, involving a finite number of well-defined rare conformations.[...]The physiological relevance of each distinct conformation can be connected to the binding of the cytoskeletal protein vinculin, suggesting an extra layer of complexity in talin-mediated mechanotransduction."
https://www.nature.com/articles/s41567-022-01808-4
#StructuralBiology #Talin #Vinculin #MechanoTransduction #MechanoBiology #Cytoskeleton
A neuronal growth cone photographed through a microscope. Actin filaments and microtubules are shown. #cellbiology
A thoughtful essay on young life scientists migrating to non-academic careers.
#academia #biotech
https://www.statnews.com/2022/11/10/tipping-point-is-coming-unprecedented-exodus-of-young-life-scientists-shaking-up-academia/
#introduction 👀 hello Mastodon community, thanks for having me!
I'm a researcher, (#digitalinclusion #digitalhumanities - www.alicjapawluczuk.com) educator & ARTIST (#endometriosis #genderhealthgap #feminism #art - www.hystera.online). I'm a Polish-Scottish-citizen-of-nowhere, currently Based in #Berlin, where I'm recovering from #Brexit. Looking fwd to connecting & exchanging ideas :)
Looking for a #PhD? #UCL is offering 40 #scholarships for fully funded PhD positions across all disciplines, available to people from any country. Deadline Jan 13th https://www.ucl.ac.uk/scholarships/research-excellence-scholarship
#introduction (I love the idea!)
I am an associate professor at the #LBBE in Lyon
This means I teach for a significant part of my time (maths, genetics) at the #IUTLyon1
In my research I study #evolution with models (#popgen, #adaptivedynamics) more #mechanistic than usual – often this leads me to study #evolution in/of biological #networks
Hello, new here like many others so I will post an #introduction .
I work in #EvolutionaryBiology , particularly phenotypic #evolution using #morphometrics and correlates with #Genomics and #Transcriptomics . After a bunch of positions abroad (postdocs and lecturer), I am currently a tenured researcher at the #Italian National Research Council and my lab is based in #Messina (which is in #Sicily).
More info on me and my lab on my website https://www.fruciano.org/
Currently, checking out Mastodon.
#JobPost: hiring an editor at Nature Ecology & Evolution
We are hiring an #editor!
Do you have a background in #ecology or #evolution, and want to be involved in a broader range of topics than your own research area?
We are particularly keen to extend the geographical representation of our #editorial team (see some possible locations in the #JobAd below). #AltAc #EditorJobs
I work as a #science #journalist for #French #newspaper Le Parisien. I write stories about #space #astronomy #archeology #biology
Je suis un #journaliste #français travaillant au #Parisien, en charge des #sciences. J'écris notamment sur #astronomie #archeologie #biologie
RT @LecuitLab@twitter.com
1st lecture @cdf1530@twitter.com next Tuesday 15th Nov. I will present & discuss in the next weeks what is known/unknown about how collective dynamics emerges from cell interactions, taking ex. from bacteria, eukaryotic cells in development & disease. Videos & pdf to follow. Hope you enjoy!
🐦🔗: https://twitter.com/LecuitLab/status/1590672070983438343
Today is #science day at #COP27. #Bioscience is crucial for understanding #climatechange.
This #PLOSBiology essay explores the potential of #biotechnology to contribute to the expansion of genetic diversity in crops as a strategy for climate resilience https://plos.io/3ITNZXQ
Would you like to work with me and my group to investigate #MembraneTraffic in cells? There is a postdoc position available in my lab in Warwick, UK. https://tinyurl.com/roylePostDocJob I'm happy to answer any questions!
#ScienceMastodon #CellBiology #microscopy #PostDoc #vacancy
I have seen a few people doing this so I guess it's my turn. Here is a list of # I'm interested in.
Science:
#CellBiology
#MembraneTraffic
#MechanoBiology
#DevBio
#Growth
#Evolution
#Morphogenesis
#Microscopy
#ImageAnalysis
#BioPhysics
#Modelling
#SoftMatter
Other fields I am curious about:
#Epistemology
#HistoryOfScience
#SocialSciences
#GenderStudies
Fun&Games:
#Fantasy
#SciFi
#VideoGames
#BoardGames
I also love #SciCom and I'm always looking for new channels to communicate science.
Currently, I mainly use #SkypeAScientist, dedicated #Discord servers, and help when my institute organizes events.
RT @spren9er@twitter.com
Global Climate Spiral
#30DayChartChallenge
#Day19 Time Series - Global Change
#Day22 Time Series - Animation
Full interactive visualization available at
https://climate-spiral.spren9er.de
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Hi everyone! For my first post/toot(?) I’m very excited to announce I’ve been appointed to senior lecturer! I feel incredibly supported and appreciated by my colleagues and wider department! Special thanks to @NathanJeffery and the EMB and HARC teams. 💀 #Anatomy #biomechanics
PhD position in Manchester, UK (BBSRC DTP): The evolution of nerves: understanding the roots of neurodegeneration – training in evolution biology, biochemistry, expansion or electron microscopy, cell culture, genetics, #scicomm – supervision: Prokop/Allan/Ronshaugen
Details: https://thenode.biologists.com/jobs/prokop
Hi #ScienceMastodon #Introduction here! I study cell fate determination and growth regulation in #Drosophila for my #PhD. Currently wrapping up at UMass Boston, and moving on to the #postdoc position soon at UMass Chan Medical School to explore new areas in epigenetics. Delighted to be here!
It's probably time for an #introduction after lurking for a while.
I am a recent addition to the Nature Structural & Molecular Biology editorial team. I have very recently handed in my PhD - I used #cryoem and #cryoet to study #structuralbiology of viruses and vesicular trafficking.
Looking forward to engage with the #science community here!
"growth is a non-monotonic function of volume in yeast cells, with maximal values around the critical size. Comparing small to normal, large and outsized cells, the transcriptome undergoes an extensive inversion that correlates with RNA polymerase II occupancy. Accordingly, highly expressed genes impose strong negative effects on growth when their DNA/mass ratio is altered. A similar transcriptomic inversion is displayed by mouse liver cells of different sizes [...] cell size is set to attain a properly balanced transcriptome and, hence, maximize growth during cell proliferation."
https://www.biorxiv.org/content/10.1101/2022.11.08.515578v1?rss=1
Very cool study from the Garcia-Manyes Lab (TheCrick) exploring the previously dark side of the energy landscape of talin’s R3 domain using magnetic tweezers! Tapia-Rojo et al. observe new rare conformational states, beyond being binary, some of them capable of binding vinculin. These states may encode a new layer of mechanosensitivity in talin's R3 domain! #mechanobiology #biophysics
https://www.nature.com/articles/s41567-022-01808-4
https://www.nature.com/articles/s41567-022-01828-0
(he/him)
Biologist currently working at the Curie Institute.
I just finished my PhD on liver development and cell polarity in mice and recently started a post-doc on fly morphogenesis.
I'm mainly interested in microscopy, image analysis, biophysics and developmental biology.