Peter Sarkies @PSarkies@qoto.org

Lectureship in Behaviour, Ecology, Evolution – AC2357NB, Centre for Biological Diversity, School of Biology Salary: £43,414 - £53,353 per annum Start Date: As soon as possible , <p>The School of Biology wishes to appoint a Lecturer to its academic staff at the Centre for Biological Diversity (CBD). &nbsp; </p> <p>&nbsp;</p> <p> The successful candidate will be an outstanding scholar of international standing in the fields of Behaviour, Ecology, or Evolution, with a strong track record in relevant research and teaching. &nbsp; </p> <p>&nbsp;</p> <p>The successful candidate will be expected to have a range of interests that strengthen and complement those within the Centre for Biological Diversity and the School of Biology in general and make an outstanding contribution to the field&rsquo;s advancement through research outputs. &nbsp; </p> <p>&nbsp;</p> <p> We may also explore potential joint positions with other Scottish-based research institutes.&nbsp; &nbsp; </p> <p>&nbsp;</p> <p> Candidates will be expected to provide international leadership in their chosen field and seek out interdisciplinary opportunities to strengthen their research and teaching. They will also hold a doctorate in biology or a cognate discipline and will be expected to teach at undergraduate and postgraduate level and supervise research students. &nbsp; </p> <p>&nbsp;</p> <p> The primary criteria for appointment will be evidence of, or clear potential to develop, an internationally-recognised research record and evidence of teaching experience at university level. &nbsp; </p> <p>&nbsp;</p> <p>Informal enquiries about this post may be directed to Professor Sue Healy, Director of the Centre for Biological Diversity (<a href="mailto:sdh11@st-andrews.ac.uk" target="_blank">sdh11@st-andrews.ac.uk</a>) or Dr Michael Morrissey, Deputy Director (<a href="mailto:mbm5@st-andrews.ac.uk" target="_blank">mbm5@st-andrews.ac.uk</a>). &nbsp; </p> <p>&nbsp;</p> <p> Applications are particularly welcome from people from the Black, Asian and Minority Ethnic (BAME) community, and other protected characteristics who are under-represented in academic posts at the University. &nbsp; &nbsp; </p> <p>&nbsp;</p> <p> Equality, diversity and inclusion are at the heart of the St Andrews experience.&nbsp; We strive to create a fair and inclusive culture demonstrated through our commitment to diversity awards (Athena Swan, Carer Positive, LGBT Charter, Race Charters and Stonewall). We celebrate diversity by promoting profiles of BAME, LGBTIQ+ staff and supporting networks including the Staff BAME Network; Staff with Disabilities Network; Staff LGBTIQ+ Network; and the Staff Parents &amp; Carers Network.&nbsp; Full details available online: <a href="https://www.st-andrews.ac.uk/hr/edi/" target="_blank">https://www.st-andrews.ac.uk/hr/edi/</a> &nbsp; </p> <p>&nbsp;</p> <p> Closing Date: 16 February 2023&nbsp; &nbsp; &nbsp;</p> <p>&nbsp;</p> <p>Please quote ref: AC2357NB&nbsp;&nbsp;&nbsp;&nbsp;</p> <p>&nbsp;</p> <p>Further Particulars:&nbsp;<a href="https://www.vacancies.st-andrews.ac.uk//ViewAttachment.aspx?enc=jmxpV+AcVus8i/wvT3FZXrrCOvCUGNWd9uca/tGZrAImjJJJdbFIJ10kgs0PLEL5dGaWVs6X23vpV1w+qJPaxiE/IcAqExh9Tsj68o1rlusdMUycsyYN1eIzlr0FK2tn" target="_blank" title="AC2357NB FPs.doc">AC2357NB FPs.doc</a></p> <p>&nbsp;</p> <p>&nbsp;</p> <p><strong>Centre for Biological Diversity, School of Biology</strong></p> <p><strong>Salary: &pound;43,414 - &pound;53,353 per annum</strong></p> <p><strong>Start Date: As soon as possible&nbsp;</strong></p>, Working Hours : Full Time Job Family : Academic School/Unit : School of Biology ,

‎Show The Daily, Ep Who Pays the Bill for Climate Change? - Dec 2, 2022

While wind farms in the region could help power and lower energy costs for at least 9 million homes, significant infrastructure upgrades would be needed to supply electricity from the region to other parts of the state.

Treatment of parasitic nematode infections in humans and livestock relies on a small arsenal of anthelmintic drugs that have historically reduced parasite burdens. However, anthelmintic resistance (AR) is increasing, and little is known about the molecular and genetic causes of resistance for most drugs. The free-living roundworm Caenorhabditis elegans has proven to be a tractable model to understand AR, where studies have led to the identification of molecular targets of all major anthelmintic drug classes. Here, we used genetically diverse C. elegans strains to perform dose-response analyses across 26 anthelmintic drugs that represent the three major anthelmintic drug classes (benzimidazoles, macrocyclic lactones, and nicotinic acetylcholine receptor agonists) in addition to seven other anthelmintic classes. First, we found that C. elegans strains displayed significant variation in anthelmintic responses across drug classes. Dose-response trends within a drug class showed that the C. elegans strains elicited similar responses within the benzimidazoles but variable responses in the macrocyclic lactones and nicotinic acetylcholine receptor agonists. Next, we compared the effective concentration estimates to induce a 10% maximal response (EC10) and slope estimates of each dose-response curve of each strain to the reference strain, N2, which enabled the identification of anthelmintics with population-wide differences to understand how genetics contribute to AR. Because genetically diverse strains displayed differential susceptibilities within and across anthelmintics, we show that C. elegans is a useful model for screening potential nematicides. Third, we quantified the heritability of responses to each anthelmintic and observed a significant correlation between exposure closest to the EC10 and the exposure that exhibited the most heritable responses. Heritable genetic variation can be explained by strain-specific anthelmintic responses within and across drug classes. These results suggest drugs to prioritize in genome-wide association studies, which will enable the identification of AR genes. ### Competing Interest Statement The authors have declared no competing interest.