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True Solid-State Electrical Conduction of Proteins shows them to be Efficient Transport Media arxiv.org/abs/2504.18552

True Solid-State Electrical Conduction of Proteins shows them to be Efficient Transport Media

While solid-state protein junctions have shown efficient electron transport over lengths that surpass those of conventional organic semiconducting systems, interfacial or contact effects may obscure the intrinsic protein charge transport properties. Therefore, contact resistance (RC) effects need to be quantified and then minimized, which poses a problem if 4-probe geometries cannot be used. Here we show how RC can be extracted quantitatively from the measured junction resistance (RP) by using the extrapolated zero-length resistance (RZLR) and short-circuit resistance (RS). We used AC (impedance spectroscopy) and DC measurements to examine charge transport in junctions of human serum albumin (HSA) and bacteriorhodopsin (bR) films with varying thicknesses. Three contact configurations, Si-Au, Au-EGaIn, and, in a micropore device (MpD), Au-Pd, were compared. While Si-Au and Au-EGaIn junctions exhibit substantial RC that we ascribe to interfacial oxides and electrostatic protein-electrode interactions, MpD effectively eliminates RC, enabling measuring the intrinsic electron transport across HSA and bR films. The exponential length dependence of RP shows a transport decay constant (beta) that varies with interfacial conditions, underscoring the role of contact engineering. By minimizing RC, exceptionally low beta values (0.7 to 1.1 per nm) are found, proving that, indeed, proteins can have outstanding charge transport efficiencies.

arXiv.org

Molecular Determinants of Orthosteric-allosteric Dual Inhibition of PfHT1 by Computational Assessment arxiv.org/abs/2504.18559

Molecular Determinants of Orthosteric-allosteric Dual Inhibition of PfHT1 by Computational Assessment

To overcome antimalarial drug resistance, carbohydrate derivatives as selective PfHT1 inhibitor have been suggested in recent experimental work with orthosteric and allosteric dual binding pockets. Inspired by this promising therapeutic strategy, herein, molecular dynamics simulations are performed to investigate the molecular determinants of co-administration on orthosteric and allosteric inhibitors targeting PfHT1. Our binding free energy analysis capture the essential trend of inhibitor binding affinity to protein from published experimental IC50 data in three sets of distinct characteristics. In particular, we rank the contribution of key residues as binding sites which categorized into three groups based on linker length, size of tail group, and sugar moiety of inhibitors. The pivotal roles of these key residues are further validated by mutant analysis where mutated to nonpolar alanine leading to reduced affinities to different degrees. The exception was fructose derivative, which exhibited a significant enhanced affinity to mutation on orthosteric sites due to strong changed binding poses. This study may provide useful information for optimized design of precision medicine to circumvent drug-resistant Plasmodium parasites with high efficacy.

arXiv.org

A Novel Solution of the Quantum Measurement Problem arxiv.org/abs/2504.18561

A Novel Solution of the Quantum Measurement Problem

In spite of the innumerable attempts to resolve the quantum measurement problem, almost since its beginning a century ago, a satisfactory solution still remains elusive. However, after the advent of quantum entanglement leading to environmental decoherence studies, a substantial leap forward has been achieved by Zurek and his associates. Their investigation has led to the existence of sturdy pointer states that survive decoherence leading to classicality although still remaining entangled with the environment and the apparatus states. But in order to avoid the inexplicable collapse postulate, Zurek invokes Everett's many world conjecture, which is not accepted by many experts. In this article, we present the observation of entanglement sudden death (ESD), demonstrating that disentanglement of the pointer states is caused by the quantum fluctuations of the electromagnetic field. We reveal that the decoherence between the pointer states and the environment is consistent with unitary evolution when the vacuum modes are included in the calculation, in analogy to the unitary evolution of the whole system in the spontaneous emission process. However, the ultimate state of the system is still subject to the totally unpredictable nature of individual quantum fluctuations, causing the stochastic appearance of an arbitrary classical state in von Neumann's collapse axiom even when the entire system evolves unitarily. Therefore, we suggest that an acceptable solution of the long standing measurement problem has finally been achieved.

arXiv.org

Joint Simulation Study of Chiral Symmetry Recovery and Transport Response in QCD at Finite Temperature and Chemical Potentials arxiv.org/abs/2504.18567

The Dirac equation: historical context, comparisons with the Schr\"odinger and Klein-Gordon equations, and elementary consequences arxiv.org/abs/2504.17797

The Dirac equation: historical context, comparisons with the Schrödinger and Klein-Gordon equations, and elementary consequences

This paper offers educational insight into the Dirac equation, examining its historical context and contrasting it with the earlier Schrödinger and Klein-Gordon (KG) equations. The comparison highlights their Lorentz transformation symmetry and potential probabilistic interpretations. We explicitly solve the free-particle dynamics in Dirac's model, revealing the emergence of negative-energy solutions. This discussion examines the Dirac Sea Hypothesis and explores the solutions' inherent helicity. Additionally, we demonstrate how the Dirac equation accounts for spin and derive the Pauli equation in the non-relativistic limit. The Foldy-Wouthuysen transformation reveals how the equation incorporates spin-orbit interaction and other relativistic effects, ultimately leading to the fine structure of hydrogen. A section on relativistic covariant notation is included to emphasize the invariance of the Dirac equation, along with more refined formulations of both the KG and Dirac equations. Designed for undergraduate students interested in the Dirac equation, this resource provides a historical perspective without being purely theoretical. Our approach underscores the significance of a pedagogical method that combines historical and comparative elements to profoundly understand the role of the Dirac equation in modern physics.

arXiv.org

An Accelerating Flat FLRW Model with Observation Constraints and Dynamic $\Lambda$ arxiv.org/abs/2504.17798

An Accelerating Flat FLRW Model with Observation Constraints and Dynamic $Λ$

In this paper, we explore power law solution of FLRW universe model that is associated with a variable cosmological term $Λ(t)$ as a linear function of $\frac{\ddot{a}}{a}, (\frac{\dot{a}}{a})^2$ and $ρ$. The model parameters were estimated on the basis of the four data sets: The Hubble 46 data, the Union 2.1 compilation data sets comprising of distance modulus of 580 SNIa supernovae at different redshifts, the Pantheon data set which contains Apparent magnitudes of 1048 SNIa supernovae at various redshifts and finally BAO data set of volume averaged distances at 5 redshifts. We employ the conventional Bayesian methodology to analyze the observational data and also the Markov Chain Monte Carlo (MCMC) technique to derive the posterior distributions of the parameters. The best fit values of Hubble parameter $H_0$ as per the four data sets are found as $61.53^{+0.453}_{-0.456}$, $ 69.270^{+0.229}_{-0.228}$, $78.116^ {+0.480}_{-0.479}$, and $ 71.318 ^{+2.473}_{-2.283}$ respectively. Off late the present value of Hubble parameters $H_0$ were empirically given as 73 and 67.7 (km/s)/Mpc using distance ladder techniques and measurements of the cosmic microwave background. The OHD+BAO+Union and ~OHD+Pan+BAO+Union combined data sets provide the best fit Hubble parameter value $H_0$ as $67.427^{+0.197}_{-0.199}$ and $74.997^{+0.143}_{-0.145}$ respectively. The various geometrical and physical properties of the model were also investigated and were found in good agreements with observations.

arXiv.org

Inconsistencies of nonmetric Einstein-Dirac-Maxwell theories and a cure for geometric flows of f(Q) black ellipsoid, toroid and wormhole solutions arxiv.org/abs/2504.17806

Inconsistencies of nonmetric Einstein-Dirac-Maxwell theories and a cure for geometric flows of f(Q) black ellipsoid, toroid and wormhole solutions

Many papers on modified gravity theories (MGTs), and metric-affine geometry have been published. New classes of black hole (BH), wormhole (WH), and cosmological solutions involving nonmetricity and torsion fields were constructed. Nevertheless, the fundamental problems of formulating nonmetric Einstein-Dirac-Maxwell (EDM), equations, and studying important nonmetric gravitational, electromagnetic and fermion effects have not been solved in MGTs. The main goal of this work is to elaborate on a model of nonmetric EDM theory as a generalisation of f(Q) gravity. We develop our anholonomic frame and connection deformation method, which allows us to decouple in a general form and integrate nonmetric gravitational and matter field equations. New classes of generated quasi-stationary solutions are defined by effective sources with Dirac and Maxwell fields, nonmetricity and torsion fields, and generating functions depending, in general, on all space-time coordinates. For respective nonholonomic parameterisations, such solutions describe nonmetric EDM deformations of BH and cosmological metrics. Variants of nonmetric BH, WH and toroid solutions with locally anisotropic polarisations of the gravitational vacuum, masses of fermions, and effective electromagnetic sources are constructed and analysed. Such nonmetric deformed physical objects can't be characterised in the framework of the Bekenstein-Hawking paradigm if certain effective horizon/ holographic configurations are not involved. We show how to define and compute other types of nonmetric geometric thermodynamic variables using generalisations of the concept of G. Perelman W-entropy.

arXiv.org

D-branes, AdS/CFT, dynamical Uhlmann Gauge, and stabilisation of a closed causal loop geometry arxiv.org/abs/2504.17832

D-branes, AdS/CFT, dynamical Uhlmann Gauge, and stabilisation of a closed causal loop geometry

I show here that if we construct D-branes not in the form of infinite superpositions of string modes, in order to satisfy the technical condition of coherence by means of eigenstates of annihilation operators, but instead insist on an approximate but much more physical and practical definition based on phase coherence, we obtain finite (and hence realistic) superpositions of string modes that would form realistic D-branes that would encode (at least as a semiclassical approximation) various quantum properties. Re-deriving the AdS/CFT duality by starting in the pre-Maldacena limit from such realistic D-branes would lead to quantum properties on the AdS side of the duality. Causal structures can be modified in various many particle systems, including strings, D-branes, photons, or spins, however, there is a distinction between the emergence of an effective causal structure in the inner degrees of freedom of a material, in the form of a correlation generated effective metric for example in a spin liquid system, and the emergence of a causal structure in an open propagating system by using classical light. I will show how an Uhlmann gauge construction would add stability to a modified causal structure that would retain the shape of a closed causal loop. Various other ideas related to the quantum origin of the string length are also discussed and an analogy of the emergence of string length from quantum correlations with the emergence of wavelength of an electromagnetic wave from coherence conditions of photon modes is presented.

arXiv.org
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