@Caroline_Bartma I think these are good targets for plasma cell derived tumors - especially if you factor in the entire cycle of protein homeostasis, with proteasome inhibitors being a big deal in the clinic. But the basic issue is what do you expect the side effect profile to be? Targeting nucleic acid synthesis is broad, but still the list of fast dividing host tissues/cells at any given timepoint might be significantly larger than those doing medium to high level protein synthesis. With plasma cells being just one big outlier.