"We show that self-renewing DRGMacs contribute to promote axon regeneration. Using single-cell transcriptomics data and CellChat to simulate intercellular communication, we reveal that macrophages express the neuroprotective and glioprotective ligand prosaposin and communicate with SGCs via the prosaposin receptor GPR37L1."

#immunology #Macrophage #neuroscience #Regeneration

https://www.pnas.org/doi/10.1073/pnas.2215906120