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'We further demonstrated that cGAS mediated inflammation by acting as a macrophage polarization switch, which promoted peritoneal macrophages and the bone marrow–derived macrophages to the inflammatory phenotype (M1) via the mitochondrial DNA–mTORC1 pathway.'
@adam_hume @cyrilpedia The impact paper also relies on the notion that M1 bad, M2 good. In reality macrophages take on a spectrum of phenotypes, and pathology mediated by them is context & phenotype dependent.
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Maybe it's because I gave up coffee, but I'm having a difficult time wrapping my head around the grammar of this sentence. To the point that it isn't clear to me what they're trying to say.