'We find that stromal and hematopoietic cells in the mouse thymus express the vitamin D receptor (Vdr) and Cyp27b1, the enzyme that produces hormonal 1,25-dihydroxyvitamin D (1,25D). Treatment of cultured thymic slices with 1,25D enhances expression of the critical medullary thymic epithelial cell transcription factor autoimmune regulator (Aire), its colocalization with the Vdr, and enhances tissue-restricted Ag gene expression.'

#Immunology #Thymus #AIRE

https://journals.aai.org/jimmunol/article/doi/10.4049/jimmunol.2300207/263850/Cutting-Edge-Aire-Is-a-Coactivator-of-the-Vitamin