#thymus

Initially, the thymus was believed to be an endocrine organ because its removal in early life caused changes in the ovaries and testes. Now, we understand these changes were linked to autoimmunity.

#thymus
#Tregs
#endocrine
#autoimmunity
#science
#history

@molosovsky

Vielen Dank, aber die Wiederentdeckung des antiken #Thymos, unterteilbar in die #Isothymia und die #Megalothymia stammt nicht von mir, sondern vom Politikwissenschaftler Francis Fukuyama in "Identität", 2019. Fand sie jedoch philosophisch und politikwissenschaftlich sehr stark und habe sie daher gerne für den deutschen Sprachraum aufgegriffen. (Anatomisch ist der antike Begriff übrigens in den #Thymus eingegangen.)

@wikinaut

https://scilogs.spektrum.de/natur-des-glaubens/weihnachten-als-auch-saekulares-fest-der-liebe-und-isothymia/

When FTOC's aren't enough:

'Contrary to two-dimensional cultures, thymic epithelial organoids maintained thymus functionality in vitro and mediated physiological T cell development upon reaggregation with T cell progenitors. The reaggregates showed in vivo-like epithelial diversity and ability to attract T cell progenitors.'
#Immunology #Preprint #Organoid #Thymus

https://www.biorxiv.org/content/10.1101/2024.03.05.583513v1?med=mas

Researchers discovered that #Bcells play an active role in teaching #Tcells not to attack the body itself. If the "training" fails, #autoimmunediseases such as #neuromyelitis can develop: http://go.tum.de/562972

#thymus #Neuroimmunology

J. Böttcher, T. Korn

Study Reveals Unexpected Importance of the #Thymus in Adults.

https://www.massgeneral.org/news/press-release/study-reveals-unexpected-importance-of-the-thymus-in-adults

"The thymus gland is often thought of as nonfunctional in adults & is sometimes #removed during #cardiac #surgery—a process known as thymectomy.
Compared with adults who did not have their thymus removed, adults who underwent thymectomy had a nearly 3-times higher risk of dying over 5 yrs & a 2-times higher risk of developing #cancer during that time."
@MennoWolff

'Useless' Organ That Doctors Often Remove Could Actually Fight #Cancer.

https://www.sciencealert.com/useless-organ-that-doctors-often-remove-could-actually-fight-cancer

"There's a small fatty gland that sits behind your sternum and is often said to be 'useless' in adulthood.

A recent retrospective study, however, suggests the thymus gland is not nearly as expendable as experts once thought."
#Cancer #Thymus

'Useless' Organ That Doctors Often Remove Could Actually Fight Cancer
There's a small fatty gland that sits behind your sternum and is often said to be 'useless' in adulthood.
https://www.sciencealert.com/useless-organ-that-doctors-often-remove-could-actually-fight-cancer #thymus #cancer #protection

https://www.sciencealert.com/useless-organ-that-doctors-often-remove-could-actually-fight-cancer #thymus #cancer #protection

If neither cancer nor an accident kills you, you'll probably die because of thymic involution (i.e. degeneration of the thymus; the gland in which T cells differentiate, develop, and mature). Even if you die of cancer, it might be the consequence of immunosenescence due to thymic involution.

So, why isn't there more research into thymic rejuvenation?

#thymus #aging #cancer #disease #death
https://en.wikipedia.org/wiki/Thymic_involution

A company with a process to generate new thymus tissue for immune system functions is receiving a $37 million award from the government's health breakthrough agency.

https://sciencebusiness.technewslit.com/?p=45277

#News #Press #Science #Business #Thymus #ImmuneSystem #TCells #ARPAH #Biotechnology #StemCells #TissueEngineering #MachineLearning #ArtificialIntelligence #Algorithms

The thymus, a small gland behind your sternum, may actually fight cancer, according to a new study. The study found that people who had their thymus removed during heart surgery had a higher risk of death and cancer than those who did not. The study suggests that the thymus, which is often considered ‘useless’ in adulthood, still plays a vital role in the immune system and should be preserved if possible.

#Thymus #Cancer #Immunity

https://www.sciencealert.com/useless-organ-that-doctors-often-remove-may-actually-fight-cancer?utm_source=flipboard&utm_content=HariTulsidas%2Fmagazine%2FMind+and+Matter

Turns out the thymus IS important after all - who would have guessed?

https://www.nejm.org/doi/full/10.1056/NEJMoa2302892

#thymus #tcells #immunology

"We evaluated the risk of death, cancer, and autoimmune disease among adult patients who had undergone thymectomy as compared with demographically matched controls who had undergone similar cardiothoracic surgery without thymectomy. T-cell production and plasma cytokine levels were also compared in a subgroup of patients."
#Immunology #Thymus

https://www.nejm.org/doi/full/10.1056/NEJMoa2302892?query=featured_home

The thymus withers away after puberty. But it may be important for adults
Removing the thymus is associated with higher rates of death and cancer, a new study finds
https://www.sciencenews.org/article/thymus-puberty-important-adults-cancer #thymus #immunology #thymectomy
#T—cell

Doctors have long considered the thymus expendable. But could removing it be fatal?
Study finds increased risk of death in adult patients who have had immune organ taken out
https://www.science.org/content/article/doctors-have-long-considered-thymus-expendable-could-removing-it-be-fatal #thymus #immunology #thymectomy #t—cell

Der #Thymus ist ein Organ, das in der Kindheit und Jugend lebenswichtig für die Entwicklung der T-Zellen ist. Danach bildet es zurück, im Studium lernten wir alle, dass es danach keine Funktion mehr habe.

Eine neue Studie deutet bei Personen, denen der Thymus entfernt wurde, darauf hin, dass man ohne Thymus häufiger schweren Infektionen und an Krebs erkrankt.

Erstaunlich, dass wir immer noch Neues über grundlegende Organfunktionen lernen.

Anm.: Kulinarisch hat der Thymus als Kalbsbries eine Bedeutung.

https://www.science.org/content/article/doctors-have-long-considered-thymus-expendable-could-removing-it-be-fatal?et_rid=724500163&et_cid=4842709

Thymusdrüse: Bei Erwachsenen doch nicht überflüssig? Langzeitstudie widerlegt gängige Lehrmeinung zum Immunorgan in unserer Brust. #Thymus #Thymusdruese #Anatomie #Immunsysystem #Medizin
https://www.scinexx.de/news/medizin/thymusdruese-bei-erwachsenen-doch-nicht-ueberfluessig/

Study reveals unexpected importance of the thymus in adults

https://medicalxpress.com/news/2023-08-reveals-unexpected-importance-thymus-adults.html

#health #medicine #thymus

The thymus may well involute during life but it's certainly not functionally redundant!

In it's absence...
- all cause mortality
- cancer risk
- risk of autoimmune disease

#thymus #immunology #health #resection #thymectomy #mortality #cancer #autoimmunedisease #medicine #MedMastodon
https://www.nejm.org/doi/full/10.1056/NEJMoa2302892

> Health Consequences of Thymus Removal in Adults

'While CCR7 is known to promote thymocyte medullary entry and negative selection, our previous studies implicate CCR4 in these processes, raising the question of whether CCR4 and CCR7 play distinct or redundant roles in central tolerance.'

#Immunology #Thymus #Tcells

https://elifesciences.org/articles/80443