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'Four people who spent three days off Earth in September 2021 experienced physical and mental changes that included modest declines in cognitive tests, stressed immune systems and genetic changes within their cells, scientists report in a package of papers published on Tuesday in the journal Nature and several other related journals.'
https://www.nytimes.com/2024/06/12/science/astronauts-space-health-inspiration4-medical-records.html
@cyrilpedia Paywall free version of that story.
https://www.pennmedicine.org/news/news-releases/2024/june/first-study-of-civilian-space-crew-charts-course-for-research-as-commercial-flight-heats-up#:~:text=I4%20crew%20exhibited%20performance%20deficits,working%20memory%2C%20and%20sensorimotor%20speed.
And of course the Nature article: https://www.nature.com/articles/d41586-024-01705-1