Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"Keaton had been on the stage longest, risen the highest, fallen the furthest, and, thanks to the medium of film which preserved his artistry, left the most indelible legacy. ‘He was,’ Orson Welles said, ‘as we’re now beginning to realise, the greatest of all the clowns in the history of the cinema.’"
John Lahr @lrb
https://www.lrb.co.uk/the-paper/v45/n02/john-lahr/puzzled-puss
"To overcome the limitations of IL-2 as a therapeutic agent, two strategies have evolved: tumor-targeted rather than systemic delivery and engineered variants of IL-2 that preferentially activate IL-2-mediated signaling through the IL-2Rβγ heterodimeric receptor without concomitantly activating IL-2Rα (CD25) and consequentially amplifying Tregs. Both strategies have been incorporated into PD1-IL2v, a bispecific antibody molecule (dubbed an immunocytokine) that combines CD8+ T cell targeting via PD-1 binding with an IL-2 variant (IL2v) defective in binding to CD25."
https://www.cell.com/immunity/fulltext/S1074-7613(22)00642-2#.Y722Hd52BG0.twitter
ON meeting your heroes
(From Gabriel Byrne's "Walking with Ghosts: A Memoir")
"This event will acknowledge the 50th anniversary of the end of the United States Public Health Service Study of Untreated Syphilis in the Negro Male at Tuskegee and Macon County, Alabama, 1932 -1972. The intention is to create a space for authentic, accurate storytelling and discussion regarding current and future opportunities for public health leaders at CDC and beyond to move from trust to trustworthiness."
https://www.cdc.gov/tuskegee/tuskegee-remembrance/index.html
"T cell-dependent bispecific antibodies induce adverse systemic changes in addition to tumor killing. This study shows how different vascular beds respond to cancer immunotherapy, suggesting that reducing leukocyte-endothelial interactions may limit the accumulation of T cells, thereby alleviating off-tumor adverse responses."
Himmels et al @emboreports
#immunology #immunotherapy #BispecificAntibody
Here's another blast from the past, an illustration by Madalena for a piece I did a while back for Lab Times about Thelial, a company set up in Lisbon to use drosophila cells for drug screens.
https://madalenaparreira.com/
cc @martinho_lab
The latest episode of the #EMBOPodcast is out.
I spoke with Steve Quake, the new head of science at CZI (taking over from @CoriBargmann) about his career, #OpenScience, cell atlases, imaging, @ReviewCommons and lots more.
You can listen to it at the link below or on any podcast app.
https://www.embo.org/podcasts/the-biologists-were-pretty-darn-good-with-their-microscopes/
'In “Queenie: Godmother of Harlem,” the forthcoming graphic novel co-authored by the writer Aurélie Lévy and the artist Elizabeth Colomba, a vivid but forgotten historical figure is brought back to life: Stephanie St. Clair, or Queenie, a Black female boss who ran an uptown numbers game during the Harlem Renaissance.'
Crashed WWII British plane with plume in shape of the structure of the MHCI molecule.
A very specific commission that I requested from https://madalenaparreira.com for a review of Dan Davis' "The Compatibility Gene" in the now defunct magazine Lab Times.
As Charles said "From so simple a beginning..."
(Fm David Quammen's "Breathless: The Scientific Race to Defeat a Deadly Virus.")
A paper that I was not aware of in @embojournal that scientific editor @HVodermaier mentioned in the #telomerase independent immortalisation discussion on the latest #EMBOPodcast episode is the finding from Lackner, Karlseder et al in #EMBOJournal 2012 of a very interesting ALT system in #Celegans
🎧 to the episode
https://www.embo.org/podcasts/alternative-immortality/
Read the paper (#OpenAccess)
https://www.embopress.org/doi/full/10.1038/emboj.2012.61
For the record, I still think that @ImmunityCP should have picked the Malevich-inspired cover Madalena did for @lferreiramoita's Tetracycline paper
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
