Box with rabbit, glazed stoneware by @hunchbacksociety
These ads are all over NY. To learn the history of this new class of weight loss & diabetes drugs, listen to my conversation with one of the pioneers in the field, Matthias Tschöp @helmholtz_munich.
Scroll down the page at the link below to hear “Obesity is a Brain Disease":
https://www.helmholtz-munich.de/en/helmholtz-pioneer-campus
#DrugDevelopment #Obesity #Diabetes #Metabolism #SciComm #SciencePodcast
The most recent Podcast I produced for EMBO was with Pavel Tomancak (and EMBO's Thomas Lemberger). One detail that might get missed in a wide ranging conversation about science, policy, science fiction and more was Pavel's passing comment on how one important consideration in his decision to return to Europe after a very productive time at UC Berkeley were serious reservations about the US healthcare system.
#Drosophila #OpenScience #DevelopmentalBiology #EMBOPodcast
My new Clinical Pipeline column is out in Nature Medicine.
It's on JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.
#Immunology #drugdiscovery #drugdevelopment #alopecia
As long as they cough up their share of the rent
"In June a Paris official made an announcement: the city would form a committee to look into the prospect of “cohabitating” with rats."
https://www.nybooks.com/articles/2023/08/17/whack-a-rat-the-rats-of-paris-vergopoulos/
"Maps 1 & 4 The Conan Map (Brest, France, 16th Century)
This Renaissance print is a copy of a vellum drawn circa 1156 at the behest of Conan IV (“the Black”), Duke of Brittany, during a dynastic dispute with King Henry II of England, who was also Count of neighboring Anjou. As shown in the inset, the image’s purpose is solely to assert power and legitimacy. The multiple lines shown in the inset (the only remaining panel of a set of three) proclaim the conquest and rule of the corresponding regions by the Duke and his kinsmen in the House of Penthièvre."
#Art #Print #Printmaking #Etching #Handmade #Cartography#ArtGallery #Maps #artmastodon
“I was forty-five years old and tired of being an artist. Besides, I owed $20,000 to relatives, finance companies, banks, and assorted bookmakers and shylocks. It was really time to grow up and sell out, as Lenny Bruce once advised.”
Mario Puzo (in Leave the Gun, Take the Cannoli)
#Books #Book #writer #reader #bookshelf #bookstodon
'Here, we used a human tonsil organoid platform to elucidate the cellular dynamics of Ag-reactive B and T cells in primary human tonsils as they responded to IIV, LAIV, and #influenza viruses. Tonsil organoids are a useful system for tracking human adaptive immunity and can recapitulate numerous aspects of the developing B and T cell response'
#Immunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00276-5
My new Clinical Pipeline column is out in Nature Medicine.
It's on JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.
'Here, we used CRISPR-based loss-of-function screens to identify a markedly limited set of ISGs that confer interferon-mediated suppression of a model alphavirus, Venezuelan equine encephalitis virus (VEEV). We show via combinatorial gene targeting that three antiviral effectors—ZAP, IFIT3, and IFIT1—together constitute the majority of interferon-mediated restriction of VEEV, while accounting for < 0.5% of the interferon-induced transcriptome.'
My new Clinical Pipeline column is out today in Nature Medicine, a look at JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.
The story of the current generation of anti-obesity drugs from early failures with leptin & ghrelin told by one of its pioneers, Matthias Tschöp. A new podcast project, you can listen to "#Obesity is a brain disease" by scrolling down at the link below.
https://www.pioneercampus.org
#science #metabolism #neuroscience #sciencecommunication #sciencepodcast #scicomm
Madalena & Jorge, the secret identity of @thehunchbacksociety revealed.
#Art #Ceramics #Stoneware #ArtGallery #Pottery #artists #artmastodon
If you're off on vacation soon, you can mine this episode of the #EMBOPodcast for reading tips, as Pavel Tomancak suggested some of his favorite Czech #SciFi authors
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com