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"Through tissue-specific manipulation of Nptx2, the authors demonstrated that the pituitary was a major source of NPTX2 in the serum, and the increased NPTX2 secretion by the pituitary affected immune balance by regulating the blood neutrophil-to-lymphocyte ratio. Intriguingly, Nptx2 up-regulation in corticotropes seemed to depend on IL-6 but not other cytokines tested."

journals.plos.org/plosbiology/

'Flies were placed in a flight simulator, which permitted free body rotation about the yaw axis. By feeding back body movements in real time to a visual display, we augmented and inverted visual feedback.'

cell.com/current-biology/fullt

Good news on :

"Among the so-called “neglected tropical diseases,” many experts believe leishmaniasis is in a class of its own in terms of the lack of progress, in the 120 years since it was first identified, to help the two million people who contract it each year.
Now, finally, that is starting to change: When Mr. Tilano’s grandson Andrés Tilano, 14, contracted leishmaniasis last year, he was treated in a clinic in Medellín, with an experimental therapy that cured his infection in days."
(Photo: Federico Rios for The New York Times).

nytimes.com/2023/12/19/health/

Finally got to know I3S Porto! A discussion of scientific publication & communication during the first year of the pandemic that could have gone on much longer. Thanks to Perpetua Pinto-do-Ó & Margarida Saraiva for the invitation.

Today:

"Feira do Prato Falante" Porto at @this_is_the_spot from 14h to 19h (rua São Victor 143 A).

It was great to be back at the IGC on Friday. I'm going to miss it.

"A contact sheet arrangement of black and white photographs by the author W.G. Sebald from a book collecting the photographic materials he used. Credit: via MIT Press and Boiler House Press"

nytimes.com/2023/12/14/arts/de

Andre Braugher is hilarious in Brooklyn Nine-Nine, but I first got to know his work through Braugher's performance as Frank Pembleton in Homicide: Life on the Street. It's a show worth revisiting, not least to watch a very talented actor at the top of his game.

Song idea for Evil Lionel Ritchie/Evil Diana Ross duet. Prato falante.
Glazed by @hunchbacksociety
@madparreira.bsky.social

madalenaparreira.com

'An artist’s rendering of a young Gorgosaurus eating a small, feathered dinosaur called Citipes. The prey animal was consumed during the last week of the Gorgosaurus’s life. Credit: Julius Csotonyi/Royal Tyrrell Museum'

nytimes.com/2023/12/08/science

If ever go survivalist, this is how I'd have the interior of my cabin

Pot & lid from @hunchbacksociety

@madparreira.bsky.socialhttps://madalenaparreira.com/Hunchbacksociety

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