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"For these reasons, we hypothesize that PTMs could have been selected throughout evolution at the flanks of aggregation-prone regions as an intrinsic factor to protect proteins against aggregation, thus expanding the current repertoire of aggregation gatekeepers."

science.org/doi/10.1126/sciadv

"We generated mice for the B cell–conditional expression of the most frequent BTG1 mutation [Gln36→His (Q36H)]. Btg1Q36H cells almost completely outcompeted their wild-type counterparts, specifically in the GC. This competitive fitness manifested as a stronger induction of MYC-dependent growth programs."

science.org/stoken/author-toke

David del Alamo & I have spent the last 18 months putting our combined experience in scientific editing, education & funding into this baby. We've been running workshops since last January & now we've launched our site 👇

fellowsherpa.com

"Look, cancer immune-metabolism is really simple, let me walk you through it."

"The only known species of caenagnathid from this time and region was Anzu, sometimes called the “chicken from hell.” Covered in feathers and sporting wings and a toothless beak, Anzu was roughly 450 to 750 pounds (200 to 340 kilograms). Despite its fearsome nickname, though, its diet is a matter of debate. It was likely an omnivore, eating both plant material and small animals."
Image: Zubin Erik Dutta / PLOS One.

theatlantic.com/science/archiv

'We show that decidual tissues of women with preconception immunity against CMV exhibit intrinsic resistance to HCMV, mounting a rapid activation of tissue-resident memory CD8+ and CD4+ T cells upon HCMV reinfection.'

cell.com/cell-reports/fulltext

Barcelona here we come - via Spain*'s excellent highspeed train network.

*unfortunately not true of Iberia as a whole

'In 1550, the so-called “father of art history” Giorgio Vasari recorded that “since Botticelli was a learned man, he wrote a commentary on part of Dante’s poem, and after illustrating the Inferno, he printed the work.” The painter also made a portrait of Dante, Vasari tells us, and drew sketches for engravings in the first Florentine edition of The Divine Comedy in 1481.'

openculture.com/2014/06/bottic

"Na exposição intitulada “As Mulheres de Maria Lamas” serão apresentadas pela primeira vez as provas originais e novas provas feitas, a partir dos negativos, por Luís Pavão, que estavam na posse da família. “Estava tudo muito bem guardado e classificado,” explica Jorge Calado. A partilha é, por isso, inédita e realiza-se no átrio da Biblioteca de Arte da Gulbenkian."

leitor.expresso.pt/semanario/s

Arriving at the end of three wonderful weeks hosted by Sidonia & Masaki Tajima at Kyoto's Center for Cancer Immunotherapy & Immunobiology.

More on the center later, but you can browse their site at the link below 👇

ccii.med.kyoto-u.ac.jp/en/

'This was Coppola’s bid to take his place among the cinema’s image-masters, such as F. W. Murnau and King Vidor, who took bare-bones stories of an abstracted simplicity—at the edge of legend—and endowed them with overwhelming power through sheer visual impact.'

newyorker.com/culture/the-fron

"Our data suggest that active Long Covid is accompanied by a blood protein signature marked by increased complement activation and thromboinflammation, including activated platelets and markers of red blood cell lysis. Tissue injury may also be complement-mediated and, in turn, activate the complement system." science.org/doi/10.1126/scienc

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