"For these reasons, we hypothesize that PTMs could have been selected throughout evolution at the flanks of aggregation-prone regions as an intrinsic factor to protect proteins against aggregation, thus expanding the current repertoire of aggregation gatekeepers."
"We generated mice for the B cell–conditional expression of the most frequent BTG1 mutation [Gln36→His (Q36H)]. Btg1Q36H cells almost completely outcompeted their wild-type counterparts, specifically in the GC. This competitive fitness manifested as a stronger induction of MYC-dependent growth programs."
#immunology
Madalena's Lion King masks, all made from paper/cardboard. @madparreira
#art #arts #theaterarts #theater #handmade
David del Alamo & I have spent the last 18 months putting our combined experience in scientific editing, education & funding into this baby. We've been running workshops since last January & now we've launched our site 👇
Vase with fishes.
Glazed stoneware by @hunchbacksociety
#art #ceramics #stoneware #handmade #artgallery #stoneware #artmastodon
https://madalenaparreira.com/Hunchbacksociety
"The only known species of caenagnathid from this time and region was Anzu, sometimes called the “chicken from hell.” Covered in feathers and sporting wings and a toothless beak, Anzu was roughly 450 to 750 pounds (200 to 340 kilograms). Despite its fearsome nickname, though, its diet is a matter of debate. It was likely an omnivore, eating both plant material and small animals."
Image: Zubin Erik Dutta / PLOS One.
#Scicomm #dinosaur #paleontology #fossils
Ceramic chess set by @madparreira.bsky.social
#art #ceramics #stoneware #handmade #artgallery #pottery #chess #arts #artmastodon
'We show that decidual tissues of women with preconception immunity against CMV exhibit intrinsic resistance to HCMV, mounting a rapid activation of tissue-resident memory CD8+ and CD4+ T cells upon HCMV reinfection.'
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00026-3
Unbaked Bunny.
Work in progress/Glazed stoneware by @hunchbacksociety #art #ceramics #stoneware #handmade #artgallery #stoneware #artstagram @madparreira.bsky.social https://madalenaparreira.com/Hunchbacksociety
'In 1550, the so-called “father of art history” Giorgio Vasari recorded that “since Botticelli was a learned man, he wrote a commentary on part of Dante’s poem, and after illustrating the Inferno, he printed the work.” The painter also made a portrait of Dante, Vasari tells us, and drew sketches for engravings in the first Florentine edition of The Divine Comedy in 1481.'
https://www.openculture.com/2014/06/botticellis-92-illustrations-of-dantes-divine-comedy.html
"Na exposição intitulada “As Mulheres de Maria Lamas” serão apresentadas pela primeira vez as provas originais e novas provas feitas, a partir dos negativos, por Luís Pavão, que estavam na posse da família. “Estava tudo muito bem guardado e classificado,” explica Jorge Calado. A partilha é, por isso, inédita e realiza-se no átrio da Biblioteca de Arte da Gulbenkian."
https://leitor.expresso.pt/semanario/semanario2673-1/html/revista-e/-e/retratos-de-vidas-escravas
Arriving at the end of three wonderful weeks hosted by Sidonia & Masaki Tajima at Kyoto's Center for Cancer Immunotherapy & Immunobiology.
More on the center later, but you can browse their site at the link below 👇
'This was Coppola’s bid to take his place among the cinema’s image-masters, such as F. W. Murnau and King Vidor, who took bare-bones stories of an abstracted simplicity—at the edge of legend—and endowed them with overwhelming power through sheer visual impact.'
"Our data suggest that active Long Covid is accompanied by a blood protein signature marked by increased complement activation and thromboinflammation, including activated platelets and markers of red blood cell lysis. Tissue injury may also be complement-mediated and, in turn, activate the complement system." #Covid #LongCovid #Virology #Immunology https://www.science.org/doi/10.1126/science.adg7942
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com