'Through adoptive transplantation of donor bone marrow stem cells carrying a mutant human amyloid precursor protein (APP) transgene into either APP-deficient knockout or normal recipient animals, we observed rapid development of AD pathological hallmarks.'
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(24)00049-3
"(...) Monet’s “Boulevard des Capucines” (1873), the teeming vista of a city that knew itself to be the capital of the 19th century.
Monet painted this from the very gallery where the First Impressionist show took place, the studio of photographer Nadar. He thus challenged photography on home ground, assimilating its plunging viewpoints, sharp angles, blur of movement, while in the painterly blending of small flickering strokes he evoked urban experience as a web of light and atmosphere."
(Monet’s ‘Boulevard des Capucines’ © Atkins Museum of Art)
https://www.ft.com/content/ee7effc5-6ad8-4b9f-8c82-82347d1afdaa
"For scientists who study the human immune system, the penny dropped at different points in the early frenetic months of the Covid-19 pandemic. Looking back now, many marvel at the realization that they witnessed and were able to chronicle something no other scientists had ever actually seen."
(Illustration: Molly Ferguson/STAT)
https://www.statnews.com/2024/03/28/covid-immune-system-response/
Bird bowl by @hunchbacksociety
#Ceramics #stoneware #pottery #Handmade #Art #stoneware #artgallery #artmastodon #hunchbacksociety https://madalenaparreira.com/Hunchbacksociety
"This series of prints was created between 2017 and 2021 and consists of several aquatints of stages, doors, caves or forests, where figures have been inserted through the technique of chine-collé, and colours added through viscosity printing."
#Prints #Printmaking #Art #ArtGallery #ArtMastodon
@madparreira.bsky.social
Dual monkey candleholder by @hunchbacksociety - could also be used to hold a pair of bananas.
#Ceramics #stoneware #pottery #Handmade #Art #stoneware #artgallery #artmastodon @madparreira.bsky.social
"Our findings expand on previous work measuring genetic ancestry effects on the gene expression response to pathogens or immune stimuli by showing that many of the ancestry-associated differences in transcriptional responses to pathogens are accompanied by epigenetic differences between ancestry groups. More generally, our data help fill a critical gap in biomedical research: the limited number of non-European ancestry individuals among cohorts designed to study immune variance in the general population and in genomic studies more generally."
#Immunology #Epigenetics
The tale of a physics graduate student working on superconductivity who ends up at an island institute built for deplorable scholars.
A fun academic novel.
#Books #bookshelf #reader
If you're in NY, this looks promising:
"Americans in Paris, at the Grey Art Museum’s airy new space on Cooper Square, evokes those days of cheap wine, curling cigarette smoke and the scent of postwar freedom. New York, despite its dynamism, had become an artistic tyranny, where Abstract Expressionist orthodoxies were proclaimed and enforced by the inquisitorial critics Clement Greenberg and Harold Rosenberg. Even the tiniest hint of figuration brought down accusations of apostasy; Willem de Kooning came in for a critical drubbing when he displayed his series of recognisable “Women”."
https://www.ft.com/content/5cbb6f33-f906-4b2a-b815-7bbde4bf1102
'Here, we showed that IL-4 cytokine signaling in GC B cells directly downregulated the transcription factor BCL6 via negative autoregulation to release cells from the GC program and to promote MBC formation.'
#GerminalCenter
#Immunology
https://www.cell.com/immunity/abstract/S1074-7613(24)00094-3
'Typewriters — the manually powered writing machines once made by Remington, Underwood and Royal — are wondrous things.
To see their magic in action, try this trick: Set a typewriter out on a table with a sheet of paper pre-rolled into its carriage, and wait. Nearly every child, and many adults, will be drawn to the beauty and specificity of the machine. They will just have to type something. A thought. A complaint. A poem. A wish.'
- Tom Hanks
(Image from Wiki Commons, Communication dans Musée des Arts et Métiers).
https://www.nytimes.com/2024/03/22/books/review/tom-hanks-reviews-a-tale-told-by-a-typewriter.html
NY sets the trend & we follow: Lisbon today.
(photo Rui Gaudencio/Publico)
“Let’s cut this sophomoric stuff, it’s not N.Y.U. anymore,” Joel Coen recalled him saying, according to a Times article in 1985. “One time I asked him to do something just to humor me, and he said, ‘Joel, this whole damn movie is just to humor you.’
https://www.nytimes.com/2024/03/20/movies/m-emmet-walsh-dead.html
Back to PRBB's beautiful beachfront Barcelona campus with David del Alamo @DARFellowsherpa to run our #NarrativeCV workshop for the @PRBBIntervals program.
For information on our courses & workshops click👇
Plate. @hunchbacksociety
#Ceramics #stoneware #pottery
#ceramic #Handmade #Art #stoneware #artgallery #Artmastodon
@madparreira.bsky.social
madalenaparreira.com/Hunchback
"Similar to other biotechnologies, genome editing faces substantial obstacles in Africa. These include regulatory uncertainty, limited access to laboratories, equipment and reagents for molecular biology work, a shortage of trained professionals, and a low rate of returnees among the diaspora. There is also little investment: most countries devote less than 1% of their gross domestic product (GDP) to research and development. The dependency of African institutions on external funding, unequal collaborations with the Global North and control of intellectual property and licensing by foreign entities further hinder progress. Additionally, there are low levels of integration of biotechnology in school and university curricula, inaccurate risk perceptions and apparent low levels of public support (often due to misinformation), and, as a consequence, inadequate political will."
"It is tempting to look for parallels with human empires. Perhaps it is impossible not to see rhymes between the natural and human worlds, and as a science journalist I’ve contributed more than my share. But just because words rhyme, it doesn’t mean their definitions align. Global ant societies are not simply echoes of human struggles for power. They are something new in the world, existing at a scale we can measure but struggle to grasp: there are roughly 200,000 times more ants on our planet than the 100bn stars in the Milky Way."
(Photo: Wan Azizi Ws/Getty)
Dont miss it, @hunchbacksociety & many other talented artists at @almeida_felipa FEIRA DO EQUINÓCIO DA PRIMAVERA/Spring Equinox Fair
March 20 & 21 from 12h to 19h.
Tomorrow & Thursday
#Ceramics #stoneware #pottery #ceramic #Handmade #Art #stoneware #artgallery #Lisbon #LisbonArt
Two birds.
@hunchbacksociety
#Ceramics #stoneware #pottery #ceramic #Handmade #Art #stoneware #artgallery #artmastodon
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com