Thiago Carvalho @cyrilpedia@qoto.org

Mariko Mabutsu Chaya #hiroshige #ukiyoe https://www.wikiart.org/en/hiroshige/mariko-mabutsu-chaya

I think I've converged on four phases of #writing large projects like a #nonfiction book. I'm curious to compare notes with others. Mine are:

1) Exploration research -> Outline / book proposal

2) Detailed research -> Chapter outlines

3) Writing -> First draft. All the content is there. And I've made a first attempt at making it readable (but it's not there yet). Here I begin to get some feedback.

I iterate between 2 and 3, chapter by chapter, and push through a draft of the entire book.

4) Refining -> New draft. This round is about readability and storytelling.

How does this compare with your process? @PessoaBrain, @WiringtheBrain,
@markdhumphries, @tdverstynen,
@thomasinselmd, @summerfieldlab, @JamesGleick, @gershbrain, @Iris, @cyrilpedia, @alexh
(Anyone?)

#Cardiovascular #deaths saw steep rise in U.S. during first year of the #COVID19 #pandemic. American Heart Association News https://www.heart.org/en/about-us/heart-and-stroke-association-statistics #COVID19 #heartdisease #publichhealth #CovidDeniers #heart #strokes #healthcare #economy

Introduction! I am a biologist and neuroscientist. I got a PhD in systems #neuroscience in the Portugues lab imaging the brain of #zebrafish larvae, where described a mesmerising circuit for heading direction in the hindbrain (https://doi.org/10.1101/2022.04.27.489672).

I recently moved to the lab of Giuliano Iurilli at IIT (Rovereto, Italy) to follow up in mice my interest in subcortical circuits for naturalistic behavior.

I'm a fan of #openscience, #Python, and unconventional paradigms. Cortex is overrated!

So this is when I am going to miss the bird site and the ability to widely broadcast some cool findings very easily. We have three new Pepper lab manuscripts to discuss. The first to make it online is beautiful work from my graduate student Laila Shehata identifying a critical role for IL4 in memory B cell selection in the GC:
https://www.biorxiv.org/content/10.1101/2023.01.26.525749v1

Still pondering these important points. As a conceptual follow-up, I'm curious to understand how connectomics enthusiasts (or anyone!) thinks about the relationship between these two Big Ideas in brain research:

Big Idea 1) Fine structural detail of the brain has functional consequences (aka the spirit behind the connectomics effort).

Big Idea 2) Across different individuals, the same functions can emerge from biological details that vary a lot (e.g. Eve Marder's work in the crab stomach).

https://www.annualreviews.org/doi/abs/10.1146/annurev-neuro-092920-121538

@vigji @albertcardona @jason_ritt @csdashm
@schoppik

This is interesting... On the final exam of #Cancer #CellBiology I asked students to make a critical assessment of the classical #HallmarksOfCancer papers by Weinberg and Hanahan, and the students were not kind. OK, I always tell them to learn to be critical, but I did not see this coming.
If you're not familiar with this, the first paper, >20y ago, was a first proper attempt to provide a conceptual framework of Cancer (spoiler: we don't really know what it is). The 1/n

https://en.wikipedia.org/wiki/The_Hallmarks_of_Cancer

Extrachromosomal #Borg elements in methane-consuming #archaea are scattered with rapidly evolving nucleotide #TandemRepeats; those within genes encode amino acid repeats that create intrinsically disordered regions @MScholmerich @BanfieldLab #PLOSBiology https://plos.io/3Y0cw3R

Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma

https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-0787/716154/Blocking-Genomic-Instability-Prevents-Acquired

Virology under the Microscope—a Call for Rational Discourse ⁦

⁦@JVirology⁩ https://journals.asm.org/doi/10.1128/jvi.00089-23

Science & its discoveries are no use without communicating them.

#podcasts are just another way to achieve this in an accessible form to both scientists and the general public.

Should be embraced whilst ensuring they contain healthy level of critique and checking for total misinformation!
#Science #academia #scicomm #communication @sciencemagazine #research

https://www.science.org/doi/10.1126/science.adg5427