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US may phase out the first generation of Covid19 vaccines:

"An expert committee advising the Food and Drug Administration recommended on Thursday that regulators phase out the original versions of the Covid-19 vaccines, allowing Americans getting their first shots to receive the updated formulations now used as boosters."

nytimes.com/2023/01/26/health/

This is the future - or rather a big part of the future - of structural biology - in situ structural biology. Great work.

RT @MaxGemmer@twitter.com

Very happy to share our recent work on protein biogenesis at the ER membrane. We analyzed 150,000 ribosomes from 1000+ tomograms of ER-derived vesicles to visualize ribosome intermediates and their downstream translocon machinery.
1/

#TeamTomo #CryoEM
nature.com/articles/s41586-022

🐦🔗: twitter.com/MaxGemmer/status/1

"Enter the nocturnal Pentalagus furnessi, or Amami rabbit, the world’s only dark-furred wild bunny. In a study published this week in the journal Ecology, Dr. Suetsugu and Hiromu Hashiwaki, a co-author also of Kobe University, posit an evolutionary bargain between Amami rabbits and B. yuwanensis. The root-sucking plants give food in exchange for seed dispersal services — something that has never been documented between a mammal and a parasitic plant."

nytimes.com/2023/01/26/science

RT @ScienceMagazine@twitter.com

The Amazon rainforest is one of the most vital major ecosystems on Earth—but it is under threat.

In this issue of Science, researchers underscore the rapid and profound changes occurring in the Amazon resulting from ever-increasing human activity. scim.ag/1iX

🐦🔗: twitter.com/ScienceMagazine/st

From Michael Bishop's 1982 Lasker acceptance speech:

'On an early morning in 1925, Robin Fahraeus became the first person to witness a biological molecule sediment in a gravitational field. You might find this an abstruse event, but Fahraeus felt otherwise. He roused his colleague, The Svedberg, from sleep with a phone call and a memorable message: “The, I have seen a dawn.”'

laskerfoundation.org/winners/1

RT @jandraRV
A postdoc position is now open in my lab! If you want to work on an NSF-funded project and are fascinated by eco-evolutionary dynamics, synthetic communities, and experimental evolution, please apply by Feb 15 recruit.ap.uci.edu/JPF08060
Please RT!

@gpollara An interesting aspect of this was discussed by the senior author of this @eLife paper, Russell Vance, who co-authored a perspective piece in @ImmunityCP in 2014 about "The Macrophage Paradox", essentially why do so many pathogens find it so cozy inside the cell type that's supposed to eat them.

cell.com/immunity/fulltext/S10

@cyrilpedia And the flip side to this shows how many layers of host defences need to be overcome by pathogens that succeed in surviving in the intracellular environment. Looking at you.... #TB #tuberculosis! 😉

"Our findings underscore the importance of cell death in defense against intracellular bacterial pathogens and provide an example of how layered and hierarchical immune pathways can provide robust defense against pathogens that have evolved a broad arsenal of virulence factors."

elifesciences.org/articles/836

The transmogrification of 'endemic' into 'benign' has been the crowning semantic achievement of the pandemic.

"Meanwhile, the White House’s id—the pundit class—keeps providing cover fire, declaring the pandemic’s toll overstated, or, in the latest twist from the University of California–San Francisco’s Monica Gandhi, offering a “scientific” rationale for doing less (i.e., stop testing, stop masking) by using “endemic” as a talisman to justify throwing our hands up in the air."
@gregggonsalves

thenation.com/article/society/

this looks good!
"Trial-history biases in evidence accumulation can give rise to apparent lapses"
from @dikshagupta
Diksha Gupta, Brian DePasquale, Charles D. Kopec, Carlos D. Brody
biorxiv.org/content/10.1101/20
#neuroscience #cognition

Very cool conference in Roscoff 🇫🇷 "Sex unfolded: sex, asex, sexes", Deadline for application: May 4, 2023 #EvolutionaryBiology
ecoevo.social/@thlenormand/109

Struggled with SIM calibration in this freezing weather - the scope likes its toasty 23°C room temperature! But now it's OK #realtimemicroscopy #cellfie

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