Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Fibroblasts were traditionally seen as structural cells, but technological advances have revealed important roles in immune function. @arthritisbham @ColesBuckleyLab &co from @KirOxford look at why #fibroblasts matters for health and disease. #PLOSBiology
https://plos.io/3JI5Cwp
Thiago Carvalho
boosted
@PLOSBiology Similar to discovering that adipocytes contribute to immune function.
More cell types may be found in the future to participate in the immune system. That is why that system is so amazingly wonderful. (To me, anyway 😏) #immunology
Thiago Carvalho
boosted
German neanderthals were more into eating elephants (https://bit.ly/3jGLmk0).
Curious as little has changed in 100k years.
---
RT @NYTScience
In a cave less than 20 miles from Lisbon, a city which has a fair claim to “seafood capital of the world," researchers discovered charred remnants of shells and claws: evidence that Neanderthals were cooking and eating crab 90,000 years ago https://nyti.ms/3jBwcwD
https://twitter.com/NYTScience/status/1623004905714724889
Thiago Carvalho
boosted
Maybe you've heard about Trikafta, the 'miracle' drug that has transformed life for people with cystic fibrosis in North America and Europe? It costs $322,000 a year, and patients take it for life.
Turns out the drug isn't available for CF patients anywhere in the developing world. And they say that's on purpose: that the maker, Vertex Pharmaceuticals, is deliberately obstructing access so as to be able to maintain that price tag.
Thiago Carvalho
boosted
📢 Uncover the mysteries of cancer evolution at the Como School on Cancer Evolution #CSCE2023 (23-26 May 2023) and join top researchers from biology & computational sciences for insights on the latest advancements.
#science #sciencemastodon #computationalbiology #biology #cancer #lifesciences #humantechnopole #italy
Thiago Carvalho
boosted
#BRD4-#PRC2 represses #transcription of T-helper 2-specific negative regulators during #Tcell #differentiation:
Brd4 interacts with #Polycomb repressive complex 2 (PRC2) to repress transcriptional expression of T-helper 2 (Th2)-negative regulators #Foxp3 and E3 #ubiqutin #ligase #Fbxw7 during lineage-specific differentiation of #Th2 cells from mouse primary naïve CD4+ T cells
https://www.embopress.org/doi/10.15252/embj.2022111473
FYI
"And while a human fatality is yet to be recorded, the experience of being stung can be excruciating. Keith Payne, a recipient of the Victoria Cross (the nation’s highest military award), has said that being stung by a platypus was worse than being struck by shrapnel."
https://www.nybooks.com/articles/2023/02/23/monotreme-dreams-platypus-matters-jack-ashby/
'In this Review, we give an overview of the regulation and cancer relevance of major metabolic pathways in which acetyl-CoA participates. We further discuss recent advances in understanding acetyl-CoA metabolism in normal tissues and tumours and the potential for targeting these pathways therapeutically.'
Thiago Carvalho
boosted
3D Printed models of proteins created from x-ray crystallography data sets. Biologic Models bridge the scientific gap between the digital and physical world. #3DPrint your own protein model at https://biologicmodels.com/3d-print-request/
"The grip of financial self-interest in US health care is becoming a stranglehold, with dangerous and pervasive consequences. No sector of US health care is immune from the immoderate pursuit of profit, neither drug companies, nor insurers, nor hospitals, nor investors, nor physician practices."
"Library warfare hit record highs during the pandemic. The American Library Association logged 729 attempts to censor resources in 2021, targeting 1,597 books, the most since the ALA started tracking requests more than two decades ago. Last year was set to exceed that total, the association says."
https://www.ft.com/content/dea4318c-6ecc-4dbd-8952-1ee025061a47
Thiago Carvalho
boosted
Martin Lewis died in obscurity in 1962; a retired art teacher who had found some success in his early career, but was largely forgotten.
Lewis spent his last three decades teaching other people how to etch. History chose Edward Hopper, but Martin Lewis was his mentor.
Great lamb & yoghurt recipe from Ottolenghi's "Simple". Bonus: it actually is simple - unlike most of his recipes, it does not require that you live next to a souk dreamed up by Italo Calvino for one of his invisible cities.
Thiago Carvalho
boosted
I'm involved in a project that uses the Twitter and Reddit APIs to help journalists send corrections/updates down the same social media pathways as the original story. With Musk and minions pulling the plug there, we're urgently investigating fediverse/Mastodon possibilities. I wish journalists would do that, too, because we could really help them out with this tool.
Experience shows that you need the big stick.
"Researchers say that the document is an ambitious effort to address searing inequities that occurred during the pandemic, but that it doesn’t do enough to force countries to share scarce resources or punish those that don’t comply."
"Establishing that Neanderthals hunted elephants is interesting, although it should not be shocking. What is impressive is the sheer quantity of meat seemingly fully exploited by Neanderthals at Neumark-Nord 1. Straight-tusked elephants were huge: Females weighed 6 tons and males up to 13 tons."
Thiago Carvalho
boosted
Etching by Madalena
Colograph of book cover by Madalena
"The works presented here are created with alternative materials rather than etched on copper. From squashed paper costumes to packaging and leather book covers, objects are inked with different processes, both intaglio and planographic."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
