Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
7/6
🦠 RNA Viruses in Ticks — Ticks that Feed on Bats! 🦇
In addition to the above studies ☝️, a new study looked at the #RNA #virome of ticks— specifically ticks that feed on bats in Sweden.
• Found 16 viruses from 11 #virus families, of which 15 were novel!
• Authors suggest that such surveillance might help identify potential zoonoses.
"Substantial viral and bacterial diversity at the bat–tick interface"
https://doi.org/10.1099/mgen.0.000942
#virology @virology #epidemiology #InfectiousDisease @eddieholmes
"As an early-stage Professor at the Institut Pasteur in Paris, Pascale made a discovery that ‘triggered a whole tsunami in the field’. She discovered the mechanisms of how L. monocytogenes uses the actin of a host to move and spread across tissue."
https://academic.oup.com/microlife/article/doi/10.1093/femsml/uqad004/7074126?login=false
Thiago Carvalho
boosted
New article! Read Immune correlates analysis of a phase 3 trial of the AZD1222 (ChAdOx1 nCoV-19) vaccine https://www.nature.com/articles/s41541-023-00630-0?utm_source=dlvr.it&utm_medium=mastodon in npj Vaccines
"We show that loss of FH leads to early alterations of mitochondrial morphology and the release of mitochondrial DNA (mtDNA) into the cytosol, where it triggers the activation of the cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING)–TANK-binding kinase 1 (TBK1) pathway and stimulates an inflammatory response that is also partially dependent on retinoic-acid-inducible gene I (RIG-I)."
'TIR has previously provided a general summary of how to write scientific reports/papers, as well as more detailed and specific advice on writing Figure legends and Materials & Methods sections. Now we turn our attention to the real food & drink of any manuscript: the Results section.'
Thiago Carvalho
boosted
Leonardo Da Vinci’s To-Do List from 1490: The Plan of a Renaissance Man
--[Calculate] the measurement of Milan and Suburbs.
--[Ask about] the measurement of the sun promised me by Maestro Giovanni Francese.
--Get the master of arithmetic to show you how to square a triangle.
Thiago Carvalho
boosted
“Who serves best doesn’t always understand.”
The Nobel-winning Polish poet Czesław Miłosz on love https://www.themarginalian.org/2018/08/16/czeslaw-milosz-love/
New Yorkers, not great news regarding your Rodent Overlords:
"We evaluated SARS-CoV-2 exposure among 79 rats captured from NYC during the fall of 2021. Our results showed that 13 of the 79 rats (16.5%) tested IgG- or IgM-positive, and partial SARS-CoV-2 genomes were recovered from all 4 rats that were qRT-PCR (reverse transcription-quantitative PCR)-positive."
#COVID #Zoonosis #Covid19 #spillover
cc @n8_upham
"AACR Breast Cancer Research Fellowships provide two-year, $120,000 grants to support postdoctoral and clinical fellows conducting basic, translational, clinical, or epidemiological research focused on breast cancer. Applications are due March 23"
"The other very important advancement in the last 5 years, is the development of single-cell regulatory genomes methods, which allow us to look at enhancer usage at a scale that simply wasn’t possible before. This is allowing us to look upstream of RNA, identifying the regulatory elements that are being dynamically used at different stages of embryogenesis. We can basically follow the regulation of a tissue’s development."
Thiago Carvalho
boosted
Sir David #Attenborough, Knight Grand Cross of the Order of St Michael And St George and close friend of Queen Elizabeth is deemed to be too communist by the legally-bound impartial #BBC controller to be broadcast. #climatebreakdown #Tories #Conservatives #climate https://www.theguardian.com/media/2023/mar/10/david-attenborough-bbc-wild-isles-episode-rightwing-backlash-fears.
Thiago Carvalho
boosted
Shocking
---
RT @JackDAshby
This is heinous. The BBC is censoring not only itself, but David Attenborough, by pulling an episode of its new flagship series on British wildlife as it focuses on UK wildlife declines... in case it upsets right-wing politicans and media. #WildIsles
https://www.theguardian.com/media/2023/mar/10/david-attenborough-bbc-wild-isles-episode-rightwing-backlash-fears
https://twitter.com/JackDAshby/status/1634213555850612736
A very good NY Times piece on the state of the science on mask use - spoiler alert: if used properly, they work.
Thiago Carvalho
boosted
Assistant Professor (tenure-track) @IUPUIBiology
Tenure-track faculty position in the Department of Biology at Indiana University Purdue University Indianapolis (IUPUI).
#ScienceJobs #job
Indianapolis #UnitedStatesUS #Fac...
https://jobrxiv.org/job/indiana-university-purdue-university-indianapolis-27778-assistant-professor-tenure-track/?feed_id=40206
A somewhat related ref that I enjoyed this week was sent to me by Zach Mainen, a perspective on LLMs by Terry Sejnowski
There are a few parts to this - for the first one, how far a descriptive approach will get us in terms of understanding function, I like what Cori Bargmann said in our conversation (which started with an analogy to the Human Genome Project and pathophysiology): understanding the components won't be an explanation, but it will set the boundaries within which the explanation(s) must be found.
In terms of AI, for me the most likely to be useful approach is comparative: to treat it as we would an alien lifeform in questions around the origin of life - but it will not necessarily map directly on to any understanding of the biological brain.
Thiago Carvalho
boosted
@NicoleCRust @MatteoCarandini @Iris @knutson_brain @schoppik @cyrilpedia
As a biologist by training, it seems self-evident that if we are to come up with preventive measures or a cure for e.g., neurodegenerative diseases, we ought to be explicitly studying biological neural networks that suffer from such diseases in the first place.
That is not to say that we aren't going to learn a lot from studies of how artificial networks work and behave. We will. But the cure, for instance, would most likely have to be of the biological kind, and even more likely, an intervention on the immune system, be it vaccination or otherwise–I'm referring to e.g., multiple sclerosis and the Epstein-Barr virus, as there may be many more such cryptic, decade-after-infection effects on the nervous system.
Scribbling about spillovers with my stylish bat-print pen pouch by Madalena
A conversation I had with Marcel LaFlamme @PLOS on #preprints, #peerreview, AI, and, of course, #ReviewCommons has just been posted on the @ReviewCommons site
"As we ask peer review to do more and more things, should we also be looking at new ways to recognize the work of reviewers?
Another way to ask that question is: should outputs other than published articles and big grants count toward research assessment and the development of scientific careers?"
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
