Thiago Carvalho @cyrilpedia@qoto.org

It was already bad enough without this, tbh. https://www.science.org/content/article/meet-the-worlds-first-known-jumping-leech-if-you-dare

#science #nature

News in Proteomics Research blog post | pQTL /GWAS studies by LCMS proteomics identifies loads of peptide level variants! https://proteomicsnews.blogspot.com/2024/06/pqtl-gwas-studies-by-lcms-proteomics.html

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#proteomics #prot-other

"The launch by #Mastodon of a new fediverse:creator #tag in link preview cards, taking you to the article author’s account. Literally a footnote. But what if this footnote is really the bigger story?

Just as #POSSE rewrote the rule book for journalists and content creators, we have the opportunity to re-centre much of the #Fediverse around carefully crafted content which is a million miles away from shitposting and reply guys."

https://www.blog-pat.ch/re-centring-the-fediverse/

My favourite part of this article is that the woman who bought the Maya vessel just...gave it back to Mexico. Like...obviously that's the right thing to do. https://www.cbc.ca/radio/asithappens/thrift-store-mayan-vase-1.7241641

'The C.I.A.’s aims were rarely popular, and its meddling was detested. The politicians who got the agency’s support suffered politically for their association with it. Many squared the circle by ruling as dictators. Washington tolerated this, perhaps even preferred it.'

https://www.newyorker.com/magazine/2024/06/17/the-cia-an-imperial-history-hugh-wilford-book-review

'Our findings position STING as a central regulator of the detrimental neuronal inflammatory stress response, integrating inflammation with glutamate signaling to cause neuronal cell death, and present it as a tractable target for treating neurodegeneration in MS.'
#Immunology #Neuroimmunology #Autoimmunity #multiplesclerosis

https://www.cell.com/cell/fulltext/S0092-8674(24)00576-2

'Meanwhile, successful fiction writers such as Norman Mailer and Truman Capote dove into journalism with zeal and facility. Capote went so far as to straight-facedly invent a new category—the nonfiction novel—with his true crime saga, In Cold Blood. “He improves on the poverty of God’s own imagination,” as Wyatt Cooper artfully phrased it.'

https://lithub.com/the-art-of-hanging-out-on-the-golden-age-of-the-celebrity-profile/

'After Fox News allowed commentators to lie about Dominion voting equipment on the air, the network ended up paying $787 million to settle a defamation lawsuit. But researchers flagging the story as it emerged—or a tech platform labeling posts about Dominion as “disputed”—is an egregious act of tyranny?'
https://www.theatlantic.com/ideas/archive/2024/06/cia-renee-censorship-conspiracy-twitter/678688/?gift=hQ-wAXx9vcfn6GAow-ESV4l120dfYQLPxUagepWugYs&utm_source=copy-link&utm_medium=social&utm_campaign=share

'A dedicated designation such as “cancer engineering” can help build a community of biologists, engineers, and clinicians that can accelerate these and other much-needed advances to provide more precise, targeted cancer care.'
https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00160-0#%20

'An interesting observation is the reduction in genetically driven immune phenotype differences in laboratory mice under rewilding conditions. Perhaps immune phenotypes may be more extreme in the absence of intensive microbial exposures and therefore have a greater impact in genetically susceptible individuals.'

https://www.nature.com/articles/s41590-024-01862-5

'In Figure 2 we illustrate the hallmarks of cancer engineering by arranging 12 cardinal fields around a tumor, and in the sections below we provide brief introductions to these fields.'

https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00185-5

Heraklion, Crete.

The sea, being all wine dark...

#Crete

'By dissolving the assembly in the current climate, Macron has offered the extreme right an unprecedented opportunity to increase its grip on parliament and, potentially, to govern France. In doing so he is deliberately playing with our lives. Many of us – women, people of colour, LGBTQIA+ people, Jews, Muslims, minorities – know how concrete and violent the consequences of such an election could be.'
https://www.theguardian.com/commentisfree/article/2024/jun/19/macron-gamble-fate-french-people-far-right

'The discovery that Anelasma’s closest living relatives are intertidal rather than epibiont barnacles also reminds us that the most likely or plausible evolutionary scenarios we can come up with may not necessarily correspond with what actually happened.'

https://www.cell.com/current-biology/fulltext/S0960-9822(14)00533-8

CAR-T cells vs bispecific monoclonal antibodies in #myeloidcells
'A retrospective study of 73 TCR patients included in trials was conducted: 36 received CAR-T and 37 received BiAbs. CAR-T produced a higher overall response rate (ORR) than BiAbs (97.1% vs. 56.8%, P=0.002). After a median of follow-up of 18.7 months, no significant difference in progression-free survival (PFS) was observed between the CAR-T and BiAbs groups (16.6 vs. 10.8 months; P=0.090), whereas overall survival (OS) was significantly longer in the CAR-T than in the BiAbs group (49.2 vs. 22.6 months; P=0.021).'
#Immunology #Immunotherapy

https://www.sciencedirect.com/science/article/pii/S2473952924002945

'Here, we established a mouse model to determine if #SARSCoV2 spike-specific matAbs inhibit immune responses elicited by recombinant protein and nucleoside-modified mRNA-lipid nanoparticle (mRNA-LNP) vaccines. We found that SARS-CoV-2 mRNA-LNP vaccines elicited robust de novo antibody responses in mouse pups in the presence of matAbs.'

#Immunology #Covid19 #Preprint #Vaccines

https://www.biorxiv.org/content/10.1101/2023.04.12.536590v1

'The mechanisms that govern how R&D funds get spent also need reform, beginning with a reappraisal of the current focus on merely paying direct research costs. Under the guise of improving efficiency and lowering administrative costs, government grants do not fully cover a variety of essential research-related expenses, such as the provisioning of well-equipped laboratories, access to well-maintained databases and high-quality technical and administrative support. A more complete ‘end-to-end’ funding model that reflects the full cost of doing research will improve the quality of scientific output.'

https://www.nature.com/articles/d41586-024-02025-0