Thiago Carvalho @cyrilpedia@qoto.org

'We discovered that the Neisseria gonorrhoeae transcriptional response to PMNs has features in common with the transcriptional response to nutrient metals and oxidative stress, which enhance Neisseria gonorrhoeae resistance to hydrogen peroxide & polymorphonuclear leukocytes.'
#Immunology #HostPathogen

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012369#sec010

'In the end, Bell Labs was ultimately undermined by the very technologies that it had created. The world that Bell Labs thrived in no longer exists: to push technological progress forward, we'll need to understand both why Bell Labs worked and why it no longer could.'
(via The Browser)

https://www.construction-physics.com/p/what-would-it-take-to-recreate-bell?ref=thebrowser.com

'MALAT1 is a highly abundant long non-coding RNA (lncRNA) that is retained in the nucleus (Sun and Ma 2019). It is consistently highly expressed across mammalian species, and its function is related to splicing regulation, the cell cycle, or the structure of the nuclear speckle (Hutchinson et al. 2007; Sun and Ma 2019). We found that MALAT1 expression is highly correlated with the DropletQC nuclear fraction measure and thus can be used to identify poor quality cells from scRNA-seq datasets. MALAT1 expression is an important technical signal that easily and quickly indicates the presence of a nucleus in droplets in scRNA-seq data.'
https://www.biorxiv.org/content/10.1101/2024.07.14.603469v1

'It is obvious that there had, indeed, been a better part of German society. If not, the Nazis would not have already needed to fill prisons and concentration camps with political opponents in 1933, years before the deportation of Jewish people began. But the identification of the anti-Nazi opposition with the conspirators that tried to kill Hitler and take power in July 1944 has always been historically dishonest. The military was certainly not the group that had sacrificed most members in the resistance against Hitler. Instead, it was the necessary element in exporting Nazi crimes from Germany to the rest of Europe.'
https://jacobin.com/2024/07/stauffenberg-hitler-plot-nazis-afd/

'Different versions of this horror have happened again and again in history. They’re still happening in places like Rwanda, Bosnia, Kosovo and East Timor, wherever one group of people permits its leaders to convince them that for their own protection, for the safety of their families and the security of their country, they must get their enemies, those alien others who until now were their neighbors.'

https://commongood.cc/reader/a-few-rules-for-predicting-the-future-by-octavia-e-butler/

'Researchers performed a systematic assessment of the circular DNA structures by analysing more than 2,500 plasmids produced in labs and sent to a company that provides services such as packaging the structures inside viruses so they can be used as gene therapies. The team found that nearly half of the plasmids had design flaws, including errors in sequences crucial to expressing a therapeutic gene.'
https://www.nature.com/articles/d41586-024-02280-1

'As instituições são quem definitivamente não está a fazer o que devia. Ou seja, investigar estes casos e garantir que há consequências. Muitas vezes, as instituições tentam varrer para debaixo do tapete e concluem que não houve qualquer má conduta.'

https://www.publico.pt/2024/07/21/ciencia/entrevista/vezes-instituicoes-tentam-varrer-fraude-cientifica-debaixo-tapete-2097794

'Consistent with previous results, most candidate SNPs were in putatively regulatory regions. Genes that contained the most extreme outliers relate to traits such as body weight or size, metabolism, immunity, fat, eye function, and the cardiovascular system'

https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011036