Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
Excited & proud to share the work of #PeijunMa, a longtime friend & collaborator who led (in #DebHung's lab @broadinstitute) the development of BacDrop (🥁), a high-throughput droplet-based scRNAseq method for bacteria, just out @cellcellpress
https://www.cell.com/cell/fulltext/S0092-8674(23)00002-8
(To be clear, I'm sharing this bc afaik I'm the only author active #onhere; Peijun & Deb led the work. I'm happy to have played a supporting role & super excited to see where the field goes next.)
Brief 🧵 (1/n):
Relic of my thesis defense dinner 20 years ago.
File under things you find cleaning the hard drive of your old computers :)
Me, Martin Weigert, Mel Cohn, Antonio Coutinho and (most important of all) my mother.
Thiago Carvalho
boosted
Thiago Carvalho
boosted
Who gives consent for study participants long gone — and who should speak for them today? Anthropologist Alyssa Bader discusses in a Q&A. https://knowablemagazine.org/article/society/2023/navigating-ethics-ancient-human-dna-research?utm_source=twitter&utm_medium=post&utm_campaign=originals
Thiago Carvalho
boosted
The wealthy know how to protect themselves and don't think COVID is mild
While most governments and public health organizations are downplaying the severity of #COVID and relying on a vaccine only strategy, do you know who is taking COVID precautions much more seriously? #DavosSafe 🧵 1/
For the one page easier to share version you can read at: https://pingthread.com/thread/1618223851212767232
@albertcardona @NicoleCRust @CoriBargmann
In which case the fly DSCAM locus would have more 'genes' than many organisms :)
Great movie - the two leads give wonderful performances, and so does Kerry Condon.
Brief warning: it has some very funny moments, but it is not a comedy (much less a "buddy movie").
'Even so, the challenge of making such a ‘living drug’ from a person’s cells extends beyond complicated designs. Safety and manufacturing problems remain to be addressed for many of the newest candidates. “There’s an explosion of very fancy things, and I think that’s great,” says immunologist Michel Sadelain at the Memorial Sloan Kettering Cancer Center in New York City. “But the complexity cannot always be brought as described into a clinical setting.”
Thiago Carvalho
boosted
Fun story about nature surprising the scientists. I learned this one from an excellent #EMBOPodcast with @CoriBargmann & @cyrilpedia.
https://www.embo.org/podcasts/our-special-feature-as-humans-is-communication/
The era was the human genome project (late 1990s). In question: how many genes do we have? Going in, they knew that a worm (with 302 neurons) had ~13K genes. The presumption was that we, with our billions of neurons (and other complexities), would have a lot more.
GeneSweep was the official betting pool, organized by Cold Spring Harbor. Of the 460 (presumably well informed scientists) who entered the competition, the winner was the one who made the SMALLEST guess (~25K). The mean guess was 62K; someone guessed as high as 200K.
The small number of genes in the human genome (25K) surprised nearly everyone.
Thiago Carvalho
boosted
On this day in 1922: Robert Holley born, won 1968 #NobelPrize for interpretation of genetic code and its role in protein synthesis #ThisDayInBiotech
Thiago Carvalho
boosted
Plant Cell webinar: Plant responses to abiotic stress. Feb 7, 3:00 PM GMT.
https://plantae.org/plant-cell-webinar-plant-responses-to-abiotic-stress/
Climate change is leading to increased exposure to abiotic stresses for plants. Register for this webinar to hear three strories of how reseach is addressing these stress responses.
Thiago Carvalho
boosted
60 (68) Asakusa River, Miyato River, Great Riverbank, 1857 #ukiyoe #hiroshige https://www.wikiart.org/en/hiroshige/60-68-asakusa-river-miyato-river-great-riverbank-1857
Print by Madalena & Constança Arouca
"Map 2 The Outer Hebrides Palimpsest (Edinburgh, Scotland, 1677)
This map is part of a series commissioned by King James VI during his attempt to pacify the “most barbarous Isle of Lewis”. It is of little strategic interest, as it charts two nearby uninhabited islets of no economic significance, but it has one unique feature: the engraver was clearly working from a palimpsest in vellum and decided to copy into the plate the still legible underlying text – a text which has absolutely no connection to the region depicted (it appears to be a list of penances compiled by the Observant Franciscan Friars of Aberdeen)."
Thiago Carvalho
boosted
A protein known as Pericentrin may contribute to intellectual disability in individuals with Down syndrome by disrupting signaling hubs that control how cells grow and develop. https://elifesciences.org/digests/78202/the-cell-biology-of-down-syndrome?utm_source=mastodon&utm_medium=social&utm_campaign=organic
Thiago Carvalho
boosted
Beautiful review indeed.
---
RT @NatureRevCancer
And the moment you've all been waiting for... Our top downloaded article in 2022: CRISPR in cancer biology and therapy by @alynakatti @biancaaadiaz @cmcaragine @nevillesanjana & @dow_lab http://go.nature.com/33Rgp4Y @NatResCancer #CRISPR #NRCtop10of2022
https://twitter.com/NatureRevCancer/status/1618974859370938369
"The revelation could shake the foundations of an entire neuroscience subfield, and prompt scientists to reconsider some of the oldest evidence that once seemed to show that oxytocin was the be-all and end-all for animal affection. Cuddles, it turns out, can probably happen without the classic cuddle hormone—even in the most classically cuddly creatures of all."
'Varios colegas y colaboradores lo corroboran. “Francis se considera el más afortunado del mundo trabajando en su laboratorio y sabiendo que por sus manos ha pasado un hallazgo tan importante”, explica el genetista Lluís Montoliu. El descubrimiento al que se refiere Montoliu son las secuencias CRISPR en microorganismos, de alto impacto internacional, que a Mojica le ha valido numerosos premios, por los que se muestra “muy agradecido”.
Thiago Carvalho
boosted
@cyrilpedia @CoriBargmann
Wonderful episode! Recommended to all. Cori’s wisdom always astounds me. Sample of a few wide ranging gems:
Cori’s PhD work led to a cancer treatment.
The notion that the human genome project was a ‘Rosetta stone’ for comparing genes across species.
Worms with their 302 neurons only have 20K genes. We with our billions neurons only have 30K genes.
The big idea that what’s sets humans apart from other species is our ability to communicate and pass along knowledge - we each do not have to invent arithmetic
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
