Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"In a multinational, phase 3, head-to-head trial, ibrutinib, a Bruton’s tyrosine kinase (BTK) inhibitor, was compared with zanubrutinib, a BTK inhibitor with greater specificity, as treatment for relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)"
#Leukemia #TyrosineKinase #BTKInhibitor
https://www.nejm.org/doi/full/10.1056/NEJMoa2211582?query=featured_home
@gpollara Particularly cool that in this case the anti-IFN abs may be having a beneficial effect, immune regulation by auto antibodies.
Thiago Carvalho
boosted
"Cistercian Numbers" are incredibly cool
It's a rare numeric system designed by 13th century monks
Each number is a based on a single vertical stick, with patterns you draw in all four quadrants off it -- top right, top left, bottom right, bottom left
A single glyph can represent a number from 1 to 9,999
It's in my recent weekly "Linkfest" newsletter, here: https://buttondown.email/clivethompson/archive/linkfest-3-cisterian-numbers-robots-that-hug-and/
Want to subscribe? Pay-what-you-want here: https://buttondown.email/clivethompson
I call it "The opposite of doomscrolling'
Thiago Carvalho
boosted
Phylodynamics of deer tick virus in North America
https://academic.oup.com/ve/advance-article/doi/10.1093/ve/vead008/7008731?rss=1
"We report that out of 501 patients with SLE analyzed, 73 (14%) present autoantibodies against IFNα (anti-IFN-Abs). The presence of neutralizing-anti-IFN-Abs in 4.2% of patients inversely correlates with low circulating IFNα protein levels, inhibition of IFN-I downstream gene signatures, and inactive global disease score."
#Immunology #Lupus #Interferon #AutoAntibodies
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00473-6
'The Stasi and the censors never felt that they had really understood Neumann’s novels or deciphered what he was saying in them. Their training assured them that all creative writing conveyed a sociopolitical message, and they suspected that Neumann’s message—hidden in cryptic prose crammed with strange allusions and enigmatic comments—was a hostile one. But they never decoded it. This was because there wasn’t any message. Neumann’s fiction was certainly opaque, but the truth was that the literary sentinels of the GDR were stupid—sometimes comically so.'
https://www.nybooks.com/articles/2023/02/09/sonnets-for-the-state-stasi-poetry-circle-oltermann/
Thiago Carvalho
boosted
Excited to share the first preprint of the lab! Great work of our first PhD student Christian Christensen investigating the role of activins in adapting gut size to food intake and promoting regenerative growth
'To provide a comprehensive analysis of somatic mutations in the normal small intestine epithelium, we used the laser capture microdissection microscopy (LCM) and whole-genome sequenced 342 individual small intestine crypts from 39 individuals (173 duodenal from 22 individuals, 47 jejunal from 5 and 122 ileal from 16) aged between 4 and 82 years. Six had a history of celiac disease (gluten enteropathy).'
Thiago Carvalho
boosted
"The team hypothesised that some of the T cells specific to SARS-CoV-2 had been activated by a herpesvirus called human #cytomegalovirus (HCMV). This pathogen is highly prevalent in the population and has also been linked to changes in the severity of #COVID19 symptoms (Alanio et al., 2022). To investigate, they stimulated pre-pandemic blood samples with different segments of SARS-CoV-2 proteins. This led them to discover a population of ‘cross-reactive’ CD4 and CD8 T cells that can recognize epitopes from both #SARSCoV2 and #HCMV"
Thiago Carvalho
boosted
Thiago Carvalho
boosted
"Since the acquisition, the company's only actions have been to silence critics of Elon, to expose journalists and others to harm, and to violate basic ethical standards and privacy laws." https://futurism.com/elon-musk-twitter-leaked-messages-twitter #Twitter
Thiago Carvalho
boosted
Feelin' majestic
by ReliableRoommate in r/capybara
Link: https://reddit.com/r/capybara/comments/10njyv7/feelin_majestic/
Thiago Carvalho
boosted
New commentary from Lisa Bauer and Debbie van Riel:
"Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity?"
https://doi.org/10.1128/mbio.02920-22
A smart, nuanced review of the literature, which concludes:
"We urgently need fundamental insight into the molecular mechanism of the neuropathogenesis of SARS-CoV-2 infections. Although different mechanisms can result in neuropathology, virus entry into the CNS and infection of CNS cells is an important one."
@mucida she was great - I wish we could do a series
Thiago Carvalho
boosted
When Thiago @cyrilpedia interviews our favorite scientist, Cori @CoriBargmann https://www.embo.org/podcasts/our-special-feature-as-humans-is-communication/
Thiago Carvalho
boosted
I get the sense that this man is just not taken seriously enough.
'Human history can be viewed as a slowly dawning awareness that we are members of a larger group. Initially our loyalties were to ourselves and our immediate family, next, to bands of wandering hunter-gatherers, then to tribes, small settlements, city-states, nations. We have broadened the circle of those we love. We have now organized what are modestly described as super-powers, which include groups of people from divergent ethnic and cultural backgrounds working in some sense together — surely a humanizing and character building experience. If we are to survive, our loyalties must be broadened further, to include the whole human community, the entire planet Earth. Many of those who run the nations will find this idea unpleasant. They will fear the loss of power. We will hear much about treason and disloyalty. Rich nation-states will have to share their wealth with poor ones. But the choice, as H. G. Wells once said in a different context, is clearly the universe or nothing."
~ Carl Sagan
(Book: Cosmos https://amzn.to/3kGZpGp)
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
